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| Description | FN-A208 fusion peptide (CAS: 809281-07-0) fuses the A208 sequence from murine laminin a1 with the fibronectin active site GRGDS via a glycine spacer, sequence Gly-Arg-Gly-Asp-Ser-Gly-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg, molecular formula C69H121N25O26, MW 1716.85 Da. It self-assembles into amyloid-like fibrils and promotes fibroblast adhesion through actin stress-fiber formation; it targets IKVAV receptors and integrins, and its activity is inhibited by EDTA. FN-A208 is a bioadhesive candidate for tissue regeneration and engineering, a tool for studying dual-activity ECM-mimetic self-assembly and cell-adhesion signaling. |
| Structure type | Linear 18-mer (GRGDS + IKVAV dual-activity fusion peptide) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| FN-A208 fusion peptide (fibronectin GRGDS – laminin α1 IKVAV fusion cell-adhesion peptide) | FN-A208; GRGDSGAASIKVAVSADR; Fibronectin-Laminin α1 fusion peptide; fusion of fibronectin RGD active site with the mouse laminin α1 chain A208 fragment; CAS 809281-07-0 | fibronectin, laminin, RGD, IKVAV, integrin, cell adhesion, self-assembly, amyloid fibrils, bioadhesive, tissue engineering | Linear 18-aa chimeric fusion adhesion peptide, sequence H-Gly-Arg-Gly-Asp-Ser-Gly-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg-OH (GRGDSGAASIKVAVSADR), free acid; N-terminus is the fibronectin RGD active site GRGDS linked via a glycine spacer to the A208 fragment of mouse laminin α1 chain (containing the IKVAV cell-adhesion epitope); side-chain net charge ~+1 (2 Arg + 1 Lys - 2 Asp; ~+1 including N-terminus +1 and C-terminus -1); hydrophobic residues ~39% (7/18: Ile1+Val2+Ala4); self-assembles into amyloid-like fibrils; no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); free acid; CAS 809281-07-0 | C69H121N25O26 | 1715.89 | 1716.88 | Free acid (-OH), no additional counterion; CAS 809281-07-0 | 18 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FNA208-01 | White to off-white powder | Store at -20°C, sealed and desiccated (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and photo-oxidation risk; note concentration/temperature-dependent self-assembly into fibrils. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Small peptide; moderate water solubility (aqueous buffers ~1–3 mg/mL). The amphipathic design (acidic RGD segment plus hydrophobic IKVAV segment) drives self-assembly into amyloid-like fibrils at higher concentration or on warming; sonication helps dissolution. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Its adhesion function is inhibited by EDTA (indicating divalent-cation-dependent integrin binding). | solid stable for ~2 years at -20°C, sealed and desiccated. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FNA208-01 | An 18-mer fusing the fibronectin GRGDS integrin-active site with the laminin α1 IKVAV epitope; it self-assembles into amyloid-like fibrils and promotes fibroblast adhesion and stress-fiber formation via integrin/IKVAV receptors, serving as a bioadhesive for tissue regeneration. | FN-A208 is a designed bioactive fusion peptide: its N-terminus carries the fibronectin integrin-binding active site GRGDS, linked through a glycine spacer to the A208 fragment of the mouse laminin α1 chain (which contains the IKVAV cell-adhesion epitope). The peptide self-assembles into amyloid-like fibrils and promotes actin stress-fiber formation and firm fibroblast attachment on material surfaces, making it a candidate bioadhesive for tissue regeneration and tissue-engineering scaffold modification. Its activity depends on both integrins (via RGD, binding αvβ3/α5β1 etc.) and the IKVAV receptor pathway, and is inhibited by EDTA (indicating divalent-cation-dependent integrin binding). It is suited to cell adhesion, neurite outgrowth (IKVAV promotes neurite extension), wound healing and regenerative-medicine research. | Cell adhesion, tissue engineering, regenerative medicine, biomaterials, bioadhesion, neurite outgrowth, extracellular-matrix mimics, wound healing | Integrins (via RGD; αvβ3/α5β1 etc., divalent-cation dependent); laminin IKVAV receptor |
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