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| Description | Dentonin TFA is a 23-residue synthetic peptide derived from the dentin sialophosphoprotein (DSPP) region, sequence Thr-Asp-Leu-Gln-Glu-Arg-Gly-Asp-Asn-Asp-Ile-Ser-Pro-Phe-Ser-Gly-Asp-Gly-Gln-Pro-Phe-Lys-Asp. Free-base C107H160N30O42, MW 2538.6 Da; TFA salt C109H161F3N30O44. The peptide contains an RGD-like cell-adhesion sequence and promotes adhesion, proliferation, and odontoblastic differentiation of dental pulp cells, inducing peritubular dentin-like tissue formation; it is a candidate active peptide for dentin/pulp regenerative medicine and is used to study DSPP mineralization regulation. The TFA salt improves aqueous solubility and storage stability. |
| Structure type | Linear 23-mer (DSPP-derived dentin-regeneration peptide, RGD-containing, TFA salt) |
| Solubility | Readily soluble in water, dilute acetic acid |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Dentonin TFA (osteogenic/dentin-regenerative peptide AC-100, MEPE-derived, trifluoroacetate salt) | Dentonin TFA; AC-100; TDLQERGDNDISPFSGDGQPFKD-OH; MEPE-derived osteogenic peptide; SIBLING RGD/SGDG peptide; free-base CAS 400090-20-2 (no separate CAS for the TFA salt) | osteogenic peptide, dentin regeneration, bone metabolism, MEPE/SIBLING, RGD integrin ligand, SGDG glycosaminoglycan binding, mineralization regulation, phosphate homeostasis, pulp/bone tissue engineering, TFA salt, hygroscopic | Linear 23-aa acidic osteogenic peptide, sequence TDLQERGDNDISPFSGDGQPFKD-OH; a synthetic functional fragment of human MEPE (Matrix Extracellular Phosphoglycoprotein, SIBLING family), also known as AC-100; contains two cell-recognition motifs: Arg-Gly-Asp (RGD, integrin-binding core) and Ser-Gly-Asp-Gly (SGDG, glycosaminoglycan attachment motif); side-chain net charge ~-4 (1 Arg + 1 Lys = +2; 5 Asp + 1 Glu = -6, plus free N-terminus +1 and free C-terminus -1), an acidic, negatively charged peptide; enriched in acidic residues (Asp/Glu/Ser), conferring calcium-binding and hydroxyapatite affinity; no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); supplied as the trifluoroacetate (TFA) salt; free-acid free base CAS 400090-20-2, no separate CAS for the TFA salt | C109H161F3N30O44 | 2651.12 | 2652.65 | TFA (trifluoroacetate); free peptide C107H160N30O42 (exact 2537.13 / avg 2538.62 Da) plus one CF3COOH (+113.99 exact / +114.02 avg Da); cross-check: free peptide + one acetate (C2H4O2) = C109H164N30O44 / 2598.67 Da, matching suppliers' Dentonin acetate data (C109H164N30O44 / 2598.6); free-base CAS 400090-20-2, no separate CAS for the TFA salt | 23 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-DENT-TFA-01 | White to off-white powder (TFA salt is strongly hygroscopic) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation risk; as an acidic peptide it binds calcium/hydroxyapatite at high calcium/ionic strength. The TFA salt is strongly hygroscopic: aliquot and store under vacuum/argon in a desiccator. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Acidic osteogenic peptide; good water solubility (aqueous/neutral buffers, >=1–2 mg/mL; aid dissolution with dilute base/ammonia). The dual RGD+SGDG motifs enable binding to both integrins and glycosaminoglycans; it has affinity for calcium/hydroxyapatite, so avoid high-calcium buffers to prevent precipitation. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The TFA lyophilate is strongly hygroscopic-weigh quickly, reseal immediately, avoid repeated freeze-thaw. For cell culture/in-vivo work, prefer a low-irritancy counterion such as acetate. | solid stable for ~2 years at -20°C, sealed and desiccated. The TFA salt is strongly hygroscopic-keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-DENT-TFA-01 | The MEPE-derived osteogenic/dentin-regenerative peptide (AC-100), bearing RGD integrin-binding and SGDG glycosaminoglycan-binding motifs, that promotes osteoprogenitor adhesion, survival and osteogenic differentiation for bone-metabolism and mineralized-tissue regeneration research. | This is the trifluoroacetate salt of Dentonin (AC-100), a synthetic functional peptide derived from the SIBLING-family matrix phosphoglycoprotein MEPE. Through its RGD motif it binds osteoprogenitor-surface integrins, and through its SGDG motif it binds membrane glycosaminoglycans; the dual-site synergy enhances cell adhesion and promotes the survival and osteogenic differentiation of immature adherent cells (with little effect on mature osteoblasts), thereby enhancing osteogenesis and mineralized-nodule formation. It also participates in phosphate homeostasis and extracellular-matrix mineralization, making it a key tool peptide for bone/dentin metabolism research. Recent work loads Dentonin onto self-assembling peptide hydrogels (e.g., RAD/Dentonin systems) for vascularized bone-defect repair and pulp-dentin regeneration. Supplied as the TFA salt: good water solubility, no oxidation/photo-oxidation risk; but the TFA salt is strongly hygroscopic, so weigh quickly and store dry/sealed; for cell/in-vivo work prefer a low-irritancy counterion such as acetate. | Bone metabolism, osteogenic differentiation, dentin/pulp regeneration, bone tissue engineering, mineralization/hydroxyapatite, phosphate homeostasis, integrin-cell adhesion, hydrogel biomaterials, SIBLING protein research | Cell-surface integrins (RGD recognition); membrane glycosaminoglycans/proteoglycans (SGDG recognition); calcium/hydroxyapatite matrix; osteoprogenitor adhesion-survival-differentiation pathways (bone mineralization and phosphate homeostasis) |
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