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| Description | Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (CAS: 135432-37-0) is the backbone-cyclized form of the fibronectin cell-binding sequence Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), molecular formula C22H35N9O9, MW 569.57 Da. Cyclization constrains the RGD motif closer to the active conformation recognized by integrins (especially alphaVbeta3), conferring higher receptor affinity and proteolytic stability than linear peptides. Cyclic RGD peptides are widely used in tumor-targeted drug delivery, anti-angiogenesis, PET/SPECT tumor-imaging probes, and integrin-targeted surface modification of biomaterials. |
| Structure type | Cyclic 6-mer (backbone-cyclized RGD, integrin-targeting) |
| Solubility | Readily soluble in water, DMSO |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) c(RGDSP) (head-to-tail amide-cyclized RGD hexapeptide) | c(RGDSP); Cyclo(Gly-Arg-Gly-Asp-Ser-Pro); cRGDSP; head-to-tail lactam-cyclized RGD hexapeptide; high-affinity integrin αvβ3 ligand/antagonist; CAS 135432-37-0 | cyclic peptide, RGD, integrin, αvβ3, αvβ5, cell-adhesion antagonist, tumor angiogenesis, tumor targeting, head-to-tail cyclization, protease-resistant | Head-to-tail lactam-cyclized 6-aa peptide, sequence Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (cRGDSP), in which G-R-G-D-S-P is cyclized by an amide bond between the N-terminal amine and the C-terminal carboxyl; it contains 6 peptide bonds (one extra cyclization amide vs. the linear form, i.e., one additional H2O lost), with no free N- or C-terminus; side-chain net charge 0 (1 Arg + 1 Asp), and no terminal charges after cyclization; hydrophobic residues ~17% (1/6: Pro); the constrained, rigid ring locks the RGD pharmacophore into the turn conformation required for integrin recognition; cyclization is by head-to-tail amide (not a disulfide); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); free cyclic peptide; CAS 135432-37-0 | C22H35N9O9 | 569.26 | 569.58 | Free cyclic peptide, no additional counterion; cyclized by a head-to-tail amide (lactam) bond, not a disulfide; CAS 135432-37-0 | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CRGDSP-01 | White to off-white powder | Store at -20°C, sealed and desiccated (~2 years). Aliquot to avoid repeated freeze-thaw. The cyclic conformation is stable; no Met/Cys/Trp-low oxidation and photo-oxidation risk. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Small cyclic peptide; good water solubility (aqueous buffers ≥2–5 mg/mL; DMSO stock solutions also possible). Head-to-tail cyclization rigidifies the conformation and markedly improves resistance to proteolysis versus linear RGD. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Aliquot aqueous solutions at -20°C to avoid repeated freeze-thaw. | solid stable for ~2 years at -20°C, sealed and desiccated. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CRGDSP-01 | A head-to-tail lactam-cyclized RGD hexapeptide c(RGDSP) that locks the RGD pharmacophore into the integrin-recognition turn; a high-affinity integrin αvβ3 ligand/antagonist with good protease resistance, used in tumor angiogenesis and integrin-targeting studies. | This is an RGD hexapeptide cyclized through a head-to-tail lactam bond, Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (cRGDSP, CAS 135432-37-0). Cyclization fixes the Arg-Gly-Asp pharmacophore into the turn conformation required for integrin recognition, markedly increasing affinity and selectivity for integrins (especially αvβ3 and αvβ5) versus linear RGD, while enhancing resistance to proteolytic degradation. c(RGDSP) competitively blocks binding of extracellular-matrix proteins (fibronectin, vitronectin) to integrins and inhibits cell adhesion, spreading and migration. Because αvβ3 is highly expressed on activated angiogenic endothelium (tumor neovasculature) and some tumor cells, c(RGDSP) and its derived probes are widely used in tumor-angiogenesis research, integrin-targeted imaging (e.g., RGD-conjugated imaging agents), anti-adhesion/anti-metastasis and antithrombotic (αIIbβ3) studies. | Integrin biology, tumor angiogenesis, tumor targeting and imaging, cell adhesion/migration, anti-metastasis, antithrombotic, drug delivery, peptide drug development | Integrin αvβ3 (and αvβ5, αIIbβ3); RGD-binding integrins; blocks ECM-integrin adhesion |
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