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| Description | GRGDSP TFA (Gly-Arg-Gly-Asp-Ser-Pro, TFA salt) is a synthetic linear hexapeptide containing the RGD motif and acts as an integrin inhibitor. Free base C₂₂H₃₇N₉O₁₀, MW 587.58 Da (CAS 91037-75-1); TFA salt C₂₄H₃₈F₃N₉O₁₂, MW 701.61 Da. By binding integrin receptors, GRGDSP inhibits integrin-mediated cell adhesion; it is used to study cell adhesion, migration, growth, and differentiation mechanisms. |
| Structure type | Linear 6-mer (RGD motif, TFA salt) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| GRGDSP TFA (Gly-Arg-Gly-Asp-Ser-Pro, trifluoroacetate salt) | GRGDSP TFA; H-Gly-Arg-Gly-Asp-Ser-Pro-OH; RGD hexapeptide; RGD core with C-terminal Pro | RGD peptide, integrin ligand, cell adhesion, cell adhesion sequence, TFA salt, Arg-Gly-Asp core | Linear 6-aa classical RGD cell-adhesion peptide, sequence H-Gly-Arg-Gly-Asp-Ser-Pro-OH (GRGDSP); contains the core RGD (Arg-Gly-Asp) cell-recognition tripeptide, with C-terminal Pro immediately following Asp (GRGDSP is a variant of the natural fibrinogen/fibronectin RGD flanking sequence); free-peptide side-chain net charge: Arg(+1)+Asp(-1)=0, plus N-terminal Gly(+1)/C-terminal Asp(-1), near neutral; no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation); supplied as the TFA salt (common counterion from HPLC purification), free-peptide formula C22H37N9O10; TFA-salt formula C24H38F3N9O12. | C22H37N9O10 | 587.27 | 587.59 | TFA salt (trifluoroacetate counterion); Table 1 lists the free-peptide formula C22H37N9O10; TFA-salt formula C24H38F3N9O12 (exact 701.26 / avg 701.61 Da) | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRGDSP-TFA-01 | White to off-white powder (TFA salt; relatively hygroscopic, requires dry storage) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation risk. The TFA salt is more hygroscopic than the free base-weigh quickly and reseal in a desiccator (or under nitrogen). | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Good water solubility: readily soluble in aqueous buffers (pH 6–8) at ≥5–10 mg/mL; the Asp carboxylate and Arg guanidinium of the RGD core confer good hydrophilicity, and C-terminal Pro adds flexibility. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Residual TFA may be mildly irritating to some sensitive cell lines; for long-term cell/in-vivo studies, consider counterion exchange to acetate or chloride; prepare solutions fresh, stable ~1 week at 4°C. | solid stable for ~2 years at -20°C, sealed and desiccated. The TFA salt is relatively hygroscopic-keep the desiccator sealed and weigh in a dry environment. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRGDSP-TFA-01 | The TFA salt of the classical RGD hexapeptide GRGDSP, bearing the Arg-Gly-Asp cell-adhesion core; a broad-spectrum integrin ligand that competitively inhibits extracellular-matrix (fibronectin/vitronectin)–integrin binding, widely used in cell adhesion, migration, spreading and integrin signaling studies. | This product is the trifluoroacetate salt of the synthetic hexapeptide H-Gly-Arg-Gly-Asp-Ser-Pro-OH (GRGDSP), one of the most widely studied RGD (Arg-Gly-Asp) cell-adhesion sequences. The RGD tripeptide motif was first identified in the cell-binding domain of fibronectin and is the core linear recognition site for integrin-family receptors (including alphaIIb beta3, alpha v beta3, alpha v beta5, alpha5 beta1) on extracellular-matrix ligands; in GRGDSP the Ser-Pro following RGD mimics the natural RGD-flanking sequence of fibronectin/vitronectin, giving broad affinity to many RGD-dependent integrins. This product competitively blocks cell adhesion, spreading and migration on immobilized fibronectin, vitronectin and RGD-coated substrates, inhibits platelet aggregation, and is used for integrin-affinity, tumor-metastasis, angiogenesis and biomaterial-surface RGD-modification studies. Supplied as the TFA salt, the common commercial form of HPLC-purified peptides; for salt-sensitive cell or in-vivo studies, counterion exchange to acetate can be performed on demand. | Cell adhesion, integrin signaling, cell migration/spreading, tumor metastasis, angiogenesis, platelet aggregation, biomaterial RGD surface modification, RGD peptide-drug conjugation | Integrins (RGD-dependent: alpha v beta3 / alpha v beta5 / alpha5 beta1 / alphaIIb beta3); fibronectin/vitronectin; cell-matrix adhesion and migration pathways |
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