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| Description | Cadherin Peptide, avian (CAS: 127650-08-2) is a synthetic decapeptide of chicken neural cadherin (N-cadherin) extracellular domain residues 76-85, C-amidated, sequence Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2, molecular formula C44H75N17O13, MW 1050.17 Da. It corresponds to the conserved adhesion-motif region (HAV-like sequence) of cadherins and competitively inhibits homotypic cadherin-mediated cell adhesion, making it useful for studying axon growth, synapse formation, cell migration during neural development, and the role of cadherins in tumor invasion, a standard tool peptide for cell-adhesion signaling research. |
| Structure type | Linear 10-mer (C-amidated chicken N-cadherin 76-85 fragment) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Cadherin Peptide, avian (chicken N-cadherin 76-85 amide, HAV cell-adhesion recognition peptide) | Cadherin Peptide, avian; H-Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2; LRAHAVDVNG-NH2; Neural-Cadherin (76-85) amide (chicken); N-cadherin trans-binding HAV peptide; CAS 127650-08-2 | cadherin, N-cadherin, HAV motif, cell-cell adhesion, trans-homophilic binding blockade, neural/tumor adhesion, C-terminal amide, short peptide | Linear 10-aa cell-adhesion recognition peptide, sequence H-Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2 (LRAHAVDVNG-NH2); a fragment of residues 76–85 within the extracellular EC1 domain of chicken (avian) neural cadherin (N-cadherin/cadherin-1), C-terminally amidated (-CONH2); contains the canonical HAV (His-Ala-Val, positions 4–6) cadherin trans-homophilic binding recognition motif at its core; side-chain net charge ~+2 (1 Arg + 1 His = +2; 1 Asp = -1; free N-terminus +1; amidated C-terminus neutral); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); supplied as the free amide (free base), not a TFA salt; CAS 127650-08-2 | C44H75N17O13 | 1049.57 | 1050.19 | Free amide (free base, no counterion salt); C-terminally amidated (-CONH2); formula C44H75N17O13; CAS 127650-08-2; suppliers (MolNova/NovoPro) report C44H75N17O13 / MW 1050.19, matching this product | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CADAV-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and photo-oxidation risk. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Good water solubility (aqueous buffers >=1–5 mg/mL). The HAV peptide is a competitive ligand for the N-cadherin trans-homophilic interface and interferes with cadherin-mediated cell-cell adhesion; no Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Not a TFA salt-less hygroscopic than TFA forms, but keep dry and sealed. | solid stable for ~2 years at -20°C, sealed and desiccated; reseal promptly and keep dry after weighing. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CADAV-01 | A C-terminally amidated 10-mer from the chicken N-cadherin EC1 domain (residues 76–85), containing the HAV trans-binding recognition motif that competitively blocks/modulates cadherin-mediated homophilic cell-cell adhesion, for neural-development, tumor-invasion and cell-adhesion research. | This is a synthetic C-terminally amidated short peptide spanning residues 76–85 of the chicken (avian) N-cadherin (cadherin-1) extracellular EC1 domain, centered on the core HAV (His-Ala-Val, positions 4–6) recognition motif of the trans-homophilic adhesion interface. Cadherins mediate calcium-dependent cell-cell adhesion through trans-homophilic EC1-domain interactions; by presenting the HAV motif in soluble form, this peptide competitively occupies adjacent cells' cadherin adhesion interfaces, reversibly interfering with or down-regulating N-cadherin-mediated cell aggregation and adherens junctions. It is widely used to study cadherin adhesion in neural development and neurite outgrowth, N-cadherin-mediated tumor invasion/migration and EMT, and as a control peptide to dissect cadherin-cadherin interactions. It is a C-terminally amidated free short peptide (not a TFA salt), with good water solubility and no oxidation/photo-oxidation risk, suitable for direct use in cell-adhesion and aggregation assays. | Cell-cell adhesion, N-cadherin, neural development, tumor invasion/migration, cadherin signaling, EMT, cell-aggregation assays, peptide biomaterial surface modification | N-cadherin (cadherin-1) EC1-domain trans-homophilic interface (HAV-motif competitive ligand); calcium-dependent cell-cell adherens junctions |
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