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| Description | GRGDSPK (CAS: 111119-28-9, EMD 56574) is the 7-residue extended peptide of the fibronectin cell-binding core, sequence Gly-Arg-Gly-Asp-Ser-Pro-Lys. Free-base C28H49N11O11, MW 715.76 Da; TFA-salt form MW ~829.8 Da. The peptide retains the complete RGD recognition sequence, competitively blocking integrin binding to fibronectin and vitronectin and inhibiting cell adhesion, aggregation, and migration; the added C-terminal lysine provides an amine for facile covalent coupling, making it suitable for immobilization on material surfaces to build integrin-responsive coatings. GRGDSPK is a high-frequency tool peptide for cell-adhesion mechanisms and biomaterials research. |
| Structure type | Linear 7-mer (fibronectin RGD-core extended peptide, TFA salt) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| GRGDSPK TFA (RGD integrin-binding heptapeptide with C-terminal Lys coupling site, trifluoroacetate salt) | GRGDSPK TFA; EMD 56574; Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH; RGD integrin-binding peptide; C-terminal-Lys immobilization peptide; TFA salt; no CAS | RGD peptide, integrin ligand, cell adhesion, biomaterial surface immobilization, C-terminal Lys coupling, integrin-fibronectin binding competition, bone/angiogenesis, TFA salt, hygroscopic | Linear 7-aa integrin-binding cell-adhesion peptide, sequence Gly-Arg-Gly-Asp-Ser-Pro-Lys-OH (GRGDSPK-OH); core Arg-Gly-Asp (RGD, positions 2–4) integrin-recognition motif flanked by flexible Gly/Ser/Pro residues; the C-terminal Lys side-chain epsilon-NH2 provides a covalent coupling/immobilization site for site-directed attachment to resins, biomaterials, hydrogels or biochip surfaces; side-chain net charge ~+1 (1 Arg + 1 Lys = +2; 1 Asp = -1; free N-terminus +1, free C-terminus -1); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); supplied as the trifluoroacetate (TFA) salt; no CAS number | C30H50F3N11O13 | 829.35 | 829.79 | TFA (trifluoroacetate); free peptide C28H49N11O11 (exact 715.36 / avg 715.77 Da, matching MedChemExpress GRGDSPK 715.76) plus one CF3COOH (+113.99 exact / +114.02 avg Da); no CAS number | 7 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRGDSPK-01 | White to off-white powder (TFA salt is strongly hygroscopic) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation risk. The TFA salt is strongly hygroscopic: aliquot and store under vacuum/argon in a desiccator. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | RGD-type small peptide with excellent water solubility (aqueous buffers >=5–10 mg/mL). The RGD motif binds multiple RGD-dependent integrins (alphaVbeta3, alphaVbeta5, alpha5beta1, etc.) and is a competitive, reversible inhibitor of integrin-fibronectin binding; the C-terminal Lys epsilon-amine can be covalently coupled to carboxyl/aldehyde surfaces via NHS/EDC, glutaraldehyde or activated esters. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The TFA lyophilate is strongly hygroscopic-weigh quickly, reseal immediately, avoid repeated freeze-thaw. For cell culture/in-vivo work, prefer a low-irritancy counterion such as acetate. | solid stable for ~2 years at -20°C, sealed and desiccated. The TFA salt is strongly hygroscopic-keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRGDSPK-01 | The classic RGD integrin-binding heptapeptide (EMD 56574); the RGD core mediates integrin recognition and cell adhesion, while the C-terminal Lys provides a site-directed covalent immobilization site, widely used for biomaterial surface functionalization, cell adhesion and integrin-signaling research. | This is the trifluoroacetate salt of the classic RGD integrin-binding heptapeptide GRGDSPK (aka EMD 56574). Its Arg-Gly-Asp (RGD) tripeptide is the most conserved integrin-recognition motif found in extracellular-matrix proteins (fibronectin, vitronectin); it is recognized by multiple RGD-dependent integrins (alphaVbeta3, alphaVbeta5, alpha5beta1, alphaVbeta6, etc.), mediating cell adhesion, spreading and survival signaling. Soluble GRGDSPK is a competitive, reversible inhibitor of integrin-fibronectin binding and can disrupt cell-ECM adhesion. Unlike plain RGD/GRGDSP, this peptide retains a C-terminal Lys whose side-chain epsilon-amine can be site-directed coupled via NHS-esters or glutaraldehyde to carboxyl/aldehyde-functionalized biomaterials, hydrogels, resins or chips, allowing the peptide to be immobilized at controlled density and orientation-a standard tool for surface endothelialization, osseointegration and cell-adhesion scaffold construction in biomaterials/tissue engineering. Good water solubility and no oxidation/photo-oxidation risk; the TFA salt is strongly hygroscopic, so weigh quickly and store dry/sealed; for cell/in-vivo work prefer a low-irritancy counterion such as acetate. | Cell adhesion, integrin signaling, biomaterial surface functionalization, tissue-engineering scaffolds, angiogenesis/tumor integrin targeting, osseointegration, peptide immobilization/bioconjugation, cell-material interactions | RGD-dependent integrins (alphaVbeta3, alphaVbeta5, alpha5beta1, alphaVbeta6, etc.); fibronectin/vitronectin integrin-binding interface; C-terminal Lys epsilon-NH2 for covalent biomaterial-surface immobilization |
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