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| Description | Fibronectin Adhesion-promoting Peptide (CAS: 125720-21-0, Heparin Binding Peptide) is derived from the C-terminal heparin-binding domain of human fibronectin, sequence Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile, molecular formula C47H74N16O10, MW 1023.19 Da. It directly promotes endothelial-cell adhesion, spreading, and migration by interacting with cell-surface heparin-binding sites, and promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. It is an active peptide for studying fibronectin heparin-binding function, vascularized tissue engineering, and cell-scaffold construction; the TFA salt improves solubility and stability. |
| Structure type | Linear 8-mer (fibronectin C-terminal heparin-binding domain, TFA salt) |
| Solubility | Readily soluble in water |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Fibronectin Adhesion-promoting Peptide TFA (octapeptide WQPPRARI, C-terminal heparin-binding domain of fibronectin) | FAP TFA; Fibronectin Adhesion-promoting Peptide; WQPPRARI; Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile; fibronectin C-terminal heparin-binding (33 kDa/HepII) octapeptide; TFA salt; free peptide CAS 125720-21-0 (the TFA salt itself has no separate CAS) | fibronectin, cell adhesion, focal adhesion, heparin-binding, heparan sulfate, extracellular matrix, biomaterial surface modification, tissue engineering, TFA salt, Trp (light-sensitive) | Linear 8-aa cell-adhesion peptide, sequence Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile (WQPPRARI), free acid; side-chain net charge ~+2 (2 Arg, no Asp/Glu; ~+2 including free N-terminus +1 and C-terminus -1); hydrophobic residues ~63% (5/8: Trp1+Pro2+Ala1+Ile1), moderately amphipathic; derived from the C-terminal heparin-binding domain (HepII/33-kDa) of human fibronectin, one of the heparin/heparan-sulfate binding sites; contains one Trp (protect from light); no Cys/Met (no disulfide/oxidation issues); supplied as the trifluoroacetate (TFA) salt; free peptide CAS 125720-21-0, the TFA salt itself has no separate CAS number | C49H75F3N16O12 | 1136.57 | 1137.23 | TFA (trifluoroacetate); free peptide C47H74N16O10 (exact 1022.58 / avg 1023.21 Da) plus one CF3COOH (+113.99 exact / +114.02 avg Da); free acid; free peptide CAS 125720-21-0, the TFA salt has no separate CAS number | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FAPTFA-01 | White to off-white powder (TFA salt is hygroscopic) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. Contains Trp-protect from light. The TFA salt is hygroscopic: aliquot and store under vacuum/argon in a desiccator. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Cationic small peptide; moderate-to-good water solubility (aqueous buffers ~1–3 mg/mL; the TFA salt aids dissolution). Hydrophobic Trp/Pro/Ile residues may cause slight turbidity at high concentration or high ionic strength-use a little DMSO (≤10%) or sonication. Protect from light (Trp). No Cys (no disulfide), no Met (no oxidation). The TFA lyophilate is hygroscopic-weigh quickly, reseal immediately, avoid repeated freeze-thaw. | solid stable for ~2 years at -20°C, sealed, desiccated and protected from light. The TFA salt is hygroscopic-keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FAPTFA-01 | The TFA salt of the fibronectin C-terminal heparin-binding octapeptide WQPPRARI, which promotes cell adhesion and focal-adhesion formation through heparin/heparan-sulfate pathways; widely used for biomaterial surface modification and tissue engineering. | This is the trifluoroacetate of the octapeptide WQPPRARI (Fibronectin Adhesion-promoting Peptide, FAP) derived from the C-terminal heparin-binding domain (HepII/33-kDa) of human fibronectin. This sequence is one of the fibronectin sites that binds heparin/heparan-sulfate proteoglycans (e.g., syndecans); when coupled to carriers such as ovalbumin it effectively supports cell attachment, and both the coupled and free peptides are potent inducers of focal-adhesion formation, activating intracellular FAK signaling and driving actin stress-fiber assembly. Unlike the classical RGD sequence (which signals through integrins α5β1/αvβ3), FAP promotes cell anchorage and spreading mainly through the heparin-binding site, often used together with RGD to scaffold materials for cell culture, tissue engineering (bone/cartilage/skin repair) and regenerative-medicine research. Supplied as the TFA salt: protect from light (Trp); the TFA salt is hygroscopic-weigh quickly and store dry/sealed; for cell culture or in-vivo work, residual TFA may affect cell viability-dialyze into acetate or hydrochloride if needed. | Cell adhesion, extracellular matrix, tissue engineering, biomaterial surface modification, wound healing, regenerative medicine, heparin binding, stem cell culture | Heparin/heparan-sulfate proteoglycans (syndecans); fibronectin C-terminal heparin-binding domain (HepII); FAK focal-adhesion signaling |
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