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| Description | Vitronectin (367-378) (CAS: 1217344-74-5) is a heparin-binding peptide derived from vitronectin residues 367-378, sequence Gly-Lys-Lys-Gln-Arg-Phe-Arg-His-Arg-Asn-Arg-Lys-Gly (GKKQRFRHRNRKG), molecular formula C₇₀H₁₂₂N₃₂O₁₆, MW 1667.92 Da. Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role in processes such as cell growth, angiogenesis, and metastasis; the peptide is used to study vitronectin-integrin interactions, heparin binding, and tumor adhesion and migration mechanisms. |
| Structure type | Linear 13-mer (vitronectin 367-378 heparin-binding region) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Vitronectin (367-378) (human vitronectin C-terminal heparin-binding 13-mer, adhesion / pluripotent stem-cell substrate peptide) | Vitronectin 367-378; VTN 367-378; GKKQRFRHRNRKG; H-Gly-Lys-Lys-Gln-Arg-Phe-Arg-His-Arg-Asn-Arg-Lys-Gly-OH; S-protein C-terminal heparin-binding peptide; serum-spreading factor fragment; heparin-binding peptide; CAS 121734-74-5 (also cataloged as 1217344-74-5 by suppliers) | cell adhesion, extracellular matrix, vitronectin, heparin-binding, heparan sulfate proteoglycan, pluripotent stem cells, self-renewal, pluripotency maintenance, chemically-defined coating substrate, cationic peptide | Linear 13-aa strongly cationic heparin-binding peptide, sequence GKKQRFRHRNRKG (H-GKKQRFRHRNRKG-OH, free C-terminal acid), corresponding to human vitronectin (S-protein, P04004) residues 367-378 in the C-terminal heparin-binding domain; side-chain net charge ~+8 (4 Arg + 3 Lys + 1 His; no acidic residues; ~+9 including N-terminus); only 1/13 hydrophobic residue (Phe), otherwise highly charged/polar; no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation); mediates adhesion and undifferentiated growth of human pluripotent stem cells (hPSC) via heparan sulfate proteoglycan (HSPG) binding. NOTE: this fragment lies in the C-terminal heparin-binding region, NOT the central RGD integrin-recognition site (RGD at ~residue 64); its primary target is heparin/HSPG rather than αvβ3 | C70H122N32O16 | 1666.97 | 1667.95 | Free base/acid (no counterion); free peptide C70H122N32O16 (exact 1666.97 / avg 1667.95 Da); CAS 121734-74-5 (also cataloged as 1217344-74-5) | 13 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-VTN367-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid freeze-thaw. No Met/Cys/Trp-low oxidation/photo-oxidation risk; the highly cationic peptide may ion-pair/precipitate at high ionic strength or in heparin-containing buffers, so control buffer composition. | 2–8°C for ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Strongly cationic and highly polar; good water solubility (dissolve in aqueous buffer; prepare coating solutions at 0.1–1 mg/mL in sterile water or dilute acetic acid/buffer for plate coating). Very low hydrophobicity (single Phe)-no DMSO needed. No Cys/Met/Trp, so low oxidation/photo-oxidation risk; being Arg/Lys-rich, it may interact electrostatically at high salt or with anionic surfaces/heparin-use as a stem-cell coating substrate per recommended dilution before plating. | solid stable ~2 years at -20°C, sealed and desiccated; moderately hygroscopic-weigh quickly and reseal, keep in a desiccator. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-VTN367-01 | A 13-aa peptide from the C-terminal heparin-binding domain of human vitronectin (GKKQRFRHRNRKG) that mediates hPSC adhesion and undifferentiated self-renewal via heparan sulfate proteoglycans, used as a chemically-defined stem-cell coating substrate. | This is a synthetic 13-mer derived from residues 367-378 of human vitronectin (S-protein, P04004), corresponding to its C-terminal heparin-binding domain. The highly cationic sequence binds cell-surface heparan sulfate proteoglycans (HSPG) and extracellular-matrix heparan sulfate, mediating attachment, spreading and undifferentiated growth of human pluripotent stem cells (hPSC). It is a standard synthetic, xeno-free/chemically-defined vitronectin-derived coating substrate used in feeder-free, defined hPSC media (E8-type systems), replacing recombinant full-length vitronectin to maintain self-renewal and pluripotency. Importantly, this fragment acts on the C-terminal heparin-binding region rather than the central RGD integrin site, so its main target is heparin/HSPG; it is also a tool peptide for studying heparin-protein interactions, cell adhesion and the stem-cell niche. | Stem-cell biology, pluripotent stem-cell culture, cell adhesion, extracellular matrix, biomaterial coating, tissue engineering, heparin binding, regenerative medicine | Heparin / heparan sulfate (HSPG); cell-surface glycosaminoglycans; hPSC attachment and self-renewal pathways (not the αvβ3 RGD site) |
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