Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of fibronectin cs1 peptide in China, also supports custom service. Welcome to wholesale bulk high quality fibronectin cs1 peptide from our factory. Contact us for more details.
| Description | Fibronectin CS1 Peptide (CAS: 136466-51-8) is the octapeptide of the CS-1 cell-adhesion domain within the type III homology connecting segment (IIICS) of human fibronectin, sequence Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr, molecular formula C38H64N8O15, MW 872.97 Da. The CS-1 domain lacks RGD and mediates cell adhesion via integrin alpha4beta1 (VLA-4), actively inhibiting tumor metastasis in spontaneous and experimental metastasis models. The peptide is used to study CS-1-mediated tumor metastasis, lymphocyte homing, and integrin signaling, a common tool in tumor biology and immunology research. |
| Structure type | Linear 8-mer (fibronectin IIICS CS-1 domain, VLA-4-binding) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Fibronectin CS1 Peptide (core CS-1 octapeptide, LDV motif VLA-4 ligand) | Fibronectin CS-1 Peptide; EILDVPST; Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr; H-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr-OH; fibronectin CS-1 fragment (1978-1985); IIICS connecting segment 1; LDV motif; VLA-4 (α4β1) integrin ligand; CAS: 136466-51-8 | cell adhesion, fibronectin CS-1, LDV motif, VLA-4 (α4β1) integrin ligand, leukocyte homing, tumor metastasis inhibition, inflammation, immune cell migration, RGD-independent adhesion | Linear 8-aa short peptide, sequence Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (EILDVPST), corresponding to the human fibronectin IIICS (type III homology connecting segment) CS-1 active fragment residues 1978–1985; contains no RGD motif-an RGD-independent cell-adhesion site; core active tripeptide LDV (Leu-Asp-Val, positions 3–5) is the specific recognition motif for VLA-4 (α4β1) integrin; free C-terminal carboxyl (-COOH) and N-terminal amino; side-chain net charge −2 (1 Asp + 1 Glu; N-terminus +1 and C-terminus −1 cancel to net −2); hydrophobic residues ~50% (Ile/Leu/Val/Pro, 4/8); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation); this is the minimal functional core of the CS-1 segment-longer CS-1 peptides (e.g., the 25-mer DELPQLVTLPHPNLHGPEILDVPST) extend N-terminally for higher affinity | C38H64N8O15 | 872.45 | 872.97 | Free acid (C-terminal -COOH); no counterion salt; no Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation); CAS: 136466-51-8 | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FNCS1-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Cys/Met/Trp-low oxidation and photo-oxidation risk. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Short peptide; moderate water solubility (aqueous buffers ~1–3 mg/mL, sonication helps); soluble in DMSO (~10–20 mg/mL). No Cys (no disulfide-no reductant needed), no Met (no oxidation), no Trp (no photo-oxidation); the simple short-peptide structure gives good solution stability; note that aggregation may occur at high concentration or high ionic strength-prepare fresh working solutions. | solid stable for ~2 years at -20°C, sealed and desiccated; no oxidation-prone or photo-labile groups-solid-state stability is good. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FNCS1-01 | The core CS-1 octapeptide EILDVPST from the fibronectin IIICS region, containing the LDV motif that is a specific VLA-4 (α4β1) integrin ligand mediating RGD-independent cell adhesion; inhibits tumor metastasis and leukocyte-endothelial adhesion. | This is the core functional octapeptide of the CS-1 (connecting segment 1) domain in the human fibronectin IIICS (type III connecting segment) region, sequence Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr. CS-1 represents a second, RGD-independent cell-adhesion pathway on fibronectin: its core LDV (Leu-Asp-Val) tripeptide is specifically recognized by VLA-4 (very late antigen-4, α4β1 integrin), mediating adhesion of VLA-4-expressing cells-lymphocytes, monocytes, eosinophils and melanoma cells-to fibronectin. Unlike the RGD–α5β1 axis, the CS1-LDV/VLA-4 axis governs leukocyte homing and inflammatory extravasation, as well as migration/invasion of VLA-4-positive tumor cells such as melanoma. This peptide acts as a VLA-4 antagonist, competitively blocking VLA-4 binding to fibronectin and VCAM-1; it inhibits tumor metastasis in both spontaneous and experimental metastasis models and suppresses leukocyte-endothelial adhesion, offering anti-inflammatory potential. EILDVPST is the minimal functional core of CS-1; longer CS-1 peptides (e.g., the 25-mer DELPQLVTLPHPNLHGPEILDVPST) extend N-terminally for higher affinity, but the core LDV tripeptide is essential for activity. Containing no RGD motif, this is a key tool for studying RGD-independent integrin adhesion, VLA-4 biology, inflammation and tumor metastasis. | Cell adhesion, integrin biology, VLA-4 (α4β1) signaling, leukocyte homing, inflammation, tumor metastasis inhibition, melanoma, immune cell migration, fibronectin IIICS/CS-1 | VLA-4 (α4β1 integrin) specific ligand; fibronectin CS-1/IIICS adhesion site; competitive VCAM-1 binding; leukocyte-endothelial adhesion |
Hot Tags: fibronectin cs1 peptide, China fibronectin cs1 peptide manufacturers, suppliers, factory
