Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of gly-arg-gly-asp-ser tfa (grgds pentapeptide tfa salt) in China, also supports custom service. Welcome to wholesale bulk high quality gly-arg-gly-asp-ser tfa (grgds pentapeptide tfa salt) from our factory. Contact us for more details.
| Description | Gly-Arg-Gly-Asp-Ser TFA (GRGDS TFA, CAS: 2828433-23-2) is the pentapeptide of the cell-binding domain of osteopontin (a glycoprotein), interacting with integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ values of \5 μM and \6.5 μM, respectively. TFA salt C₁₉H₃₁F₃N₈O₁₁, MW 604.49 Da. GRGDS is used to competitively inhibit integrin-mediated cell adhesion and to study RGD-integrin interactions, osteopontin signaling, and the role of cell adhesion in tumor and bone metabolism. |
| Structure type | Linear RGD pentapeptide (TFA salt) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| GRGDS TFA (Gly-Arg-Gly-Asp-Ser trifluoroacetate; the canonical fibronectin cell-binding sequence, RGD gold-standard peptide) | GRGDS TFA; Gly-Arg-Gly-Asp-Ser; H-Gly-Arg-Gly-Asp-Ser-OH; the central cell-binding-domain (III10 module) sequence identified from fibronectin by Pierschbacher/Ruoslahti (1984); RGD gold-standard peptide; TFA salt; CAS 282843-23-2 | cell adhesion peptide, RGD motif, gold standard, fibronectin, alpha5 beta1 ligand, cell adhesion/spreading/migration, biomaterial surface functionalization, tissue engineering, integrin antagonist development, TFA salt, hygroscopic | Linear pentapeptide, sequence Gly-Arg-Gly-Asp-Ser (GRGDS), H-Gly-Arg-Gly-Asp-Ser-OH; free N-terminal amine and free C-terminal carboxyl; near-neutral net charge (zwitterionic: 1 Arg - 1 Asp, N-terminus +, C-terminus -, ~0 at neutral pH); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); the canonical cell-binding sequence identified in 1984 by Pierschbacher and Ruoslahti from the central cell-binding domain (III10/FIII10 module) of human fibronectin-the gold-standard peptide of the RGD-integrin field; compared with RGDS it has an extra N-terminal Gly, bringing the RGD core closer to the native fibronectin conformation; the Asp side-chain carboxyl together with Gly and the Arg side chain forms the integrin-recognition triad; supplied as the trifluoroacetate (TFA) salt | C19H31F3N8O11 | 604.21 | 604.50 | TFA (trifluoroacetate); free peptide C17H30N8O9 (exact ~490.2 / avg ~490.5 Da) plus one CF3COOH (~+114.0 Da); CAS 282843-23-2. For cell-culture or in-vivo work requiring a low-irritancy counterion, consider switching to the acetate salt. | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRGDSTFA-01 | White to off-white powder (TFA salt is strongly hygroscopic) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and photo-oxidation risk. The TFA salt is strongly hygroscopic: aliquot and store sealed in a desiccator. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Small zwitterionic peptide with good water solubility (mg/mL grade in pure water/aqueous buffer, near-neutral and readily soluble). No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The TFA lyophilate is strongly hygroscopic-weigh quickly after opening, reseal immediately, and avoid repeated freeze-thaw. As a biomaterial-surface functionalization ligand, dissolve and coat/conjugate onto scaffolds or substrates; as a soluble competitor, prepare working solutions directly in medium or buffer. For cell or in-vivo work requiring a low-irritancy counterion, consider the acetate salt. | solid stable for ~2 years at -20°C, sealed and desiccated. The TFA salt is strongly hygroscopic-keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRGDSTFA-01 | The trifluoroacetate salt of GRGDS, the canonical fibronectin cell-binding pentapeptide identified by Pierschbacher/Ruoslahti in 1984-the RGD gold standard-that efficiently binds alpha5 beta1 (and alphaV beta3) integrins to mediate cell adhesion, spreading and migration. | GRGDS is the canonical Arg-Gly-Asp (RGD) cell-binding sequence identified in 1984 by Pierschbacher and Ruoslahti in the central cell-binding domain (FIII10 module) of human fibronectin, and remains the gold-standard peptide of the RGD-integrin field. Its RGD triad (Arg side chain, Gly, Asp side-chain carboxyl) efficiently binds alpha5 beta1 (and cross-recognizes alphaV beta3), mediating cell adhesion, spreading and migration on fibronectin and initiating FAK/paxillin focal-adhesion signaling. Widely used: (1) functionalizing biomaterial/scaffold surfaces with RGD ligands to promote cell attachment, spreading and tissue regeneration; (2) cell seeding and differentiation studies in tissue engineering and regenerative medicine; (3) mechanistic studies of integrin-fibronectin interaction and RGD signaling; (4) reference/screening peptides in integrin antagonist development (anti-platelet GPIIb/IIIa, anti-adhesion oncology). Note that linear GRGDS has lower affinity than cyclized RGD analogues (e.g., cyclo-RGDfK) and is used mainly for immobilization and controls. Supplied as the TFA salt, which is strongly hygroscopic-weigh quickly and store dry/sealed; for cell culture or in-vivo work, prefer a low-irritancy counterion such as acetate. | Cell adhesion, integrin biology, RGD signaling, biomaterial surface functionalization, tissue engineering/regenerative medicine, integrin antagonist development, cell spreading and migration | Integrin alpha5 beta1 (primary), alphaV beta3 and other RGD-dependent integrins; cell-ECM adhesion, spreading, migration and FAK/focal-adhesion signaling |
Hot Tags: gly-arg-gly-asp-ser tfa (grgds pentapeptide tfa salt), China gly-arg-gly-asp-ser tfa (grgds pentapeptide tfa salt) manufacturers, suppliers, factory
