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| Description | HBcAg residues 128–140, containing B-/T-cell sites; the core protein is a major target of cellular immunity in HBV infection; used for HBV responses and therapeutic vaccines. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Hepatitis B Virus Core (128-140) | HBV Core 128-140; HBcAg 128-140; TPPAYRPPNAPIL; CD4 Th epitope; CAS 160015-13-4 | HBV,core antigen,CD4 epitope,HLA-DR,therapeutic vaccine,HBcAg VLP | H-Thr-Pro-Pro-Ala-Tyr-Arg-Pro-Pro-Asn-Ala-Pro-Ile-Leu-OH (HBV core antigen HBcAg 128-140; immunodominant MHC-II CD4+ T helper epitope, promiscuous for human HLA-DR / murine I-A^b; contains 1 Tyr - light protection; 5 Pro residues) | C66H103N17O17 | 1405.77 | 1406.65 | Conventional synthetic free peptide, salt form not specified; per supplier COA (synthetic peptides mostly TFA salt) | 13 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-HBVC128-01 | White to off-white powder | Store at -20°C or below (recommended -20°C±5°C), dry, sealed, light-protected (contains 1 Tyr - prevent photo-oxidation); aliquot to avoid repeated freeze-thaw | 2–8°C, sealed, dry and light-protected, for days to weeks (short-term transport/storage) | Contains 5 Pro plus hydrophobic Ile/Leu/Ala; moderately soluble - usually soluble in water or dilute acetic acid; if poorly soluble, pre-dissolve in a small volume of DMSO (5-10 mg/mL stock) then dilute with PBS/culture medium. Prepare fresh; aliquot at -20°C; avoid repeated freeze-thaw; protect from light | powder stable for ~2 years when dry, light-protected and sealed; protect from moisture; aliquot promptly after opening and keep with desiccant |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-HBVC128-01 | HBV core 128-140 (TPPAYRPPNAPIL), immunodominant MHC-II CD4+ T helper epitope, HLA-DR restricted. | HBV core 128-140 is a classic immunodominant CD4+ T helper (Th) epitope of HBcAg with promiscuous MHC class II restriction (multiple human HLA-DR alleles; the corresponding murine I-A^b epitope is 129-140 = PPAYRPPNAPIL, i.e. lacking the N-terminal Thr). It supports HBV-specific B-cell and CD8+ T-cell responses and is widely used in hepatitis B vaccine design, HBcAg virus-like particle (VLP) carrier studies and assessment of T-cell immunity in chronic HBV infection. | Hepatitis B virus immunology,CD4+ T helper epitopes,Therapeutic HBV vaccines,HBcAg VLP vaccine carriers,Chronic HBV T-cell responses | Presented by human HLA-DR / murine MHC-II I-A^b; recognized by HBcAg-specific CD4+ T helper cells |
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