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| Description | A pathogenic fragment of mouse cardiac myosin heavy chain (Myhc-α), acetate salt, inducing experimental autoimmune myocarditis (EAM); used for cardiac autoimmunity, Th17/Th1 infiltration and dilated-cardiomyopathy models. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Myosin H Chain Fragment, mouse acetate | Cardiac myosin heavy chain-alpha fragment (mouse) acetate, Ac-RSLKLMATLFSTYASADR, MyHC-alpha 614-631, EAM-inducing peptide, MCE HY-P2464 acetate form | Experimental autoimmune myocarditis (EAM), Cardiac myosin heavy chain-alpha, Disease-model-inducing peptide, BALB/c mouse, CD4+ T cell epitope | Ac-RSLKLMATLFSTYASADR (H-N-Acetyl-Arg-Ser-Leu-Lys-Leu-Met-Ala-Thr-Leu-Phe-Ser-Thr-Tyr-Ala-Ser-Ala-Asp-Arg-OH, linear 18-mer, N-terminally acetylated; acetate salt added) | C93H153N25O30S | 2132.09 | 2133.45 | Acetate salt (free N-acetyl peptide C91H149N25O28S/2073.40 + 1 CH3COOH C2H4O2) | 18 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MYH-01 | powder, white to off-white solid (MCE HY-P2464 series, purity >=98% HPLC) | Store frozen below -20 C (preferably -80 C), dry and tightly sealed, moisture-protected; acetate salt is hygroscopic and must be sealed against moisture (approx. 2 years at -80 C, approx. 1 year at -20 C) | Short-term at 4 C sealed and dry; after reconstitution, aliquot and store at -80 C for up to 6 months or -20 C for up to 1 month; avoid repeated freeze-thaw | Somewhat hydrophilic due to 2 Arg and 1 Lys (net charge +1); MCE data show solubility ~16.67 mg/mL in water (8.04 mM, with sonication) and ~12.5 mg/mL in DMSO (6.03 mM). Reconstitute in sterile water or PBS; sonicate if difficult to dissolve. Contains 1 Met (oxidation-prone); avoid oxidants. For EAM induction, typically emulsify with CFA | powder stored dry and sealed, approx. 2 years at -80 C / 1 year at -20 C; acetate salt is strongly hygroscopic, weigh quickly after opening and store under inert gas; Met residue is oxidation-sensitive, avoid prolonged air exposure |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-MYH-01 | Mouse cardiac myosin heavy chain-alpha (MyHC-alpha 614-631) fragment acetate (Ac-RSLKLMATLFSTYASADR), used to induce experimental autoimmune myocarditis (EAM) in BALB/c mice. | This is the mouse alpha-cardiac myosin heavy chain (MyHC-alpha) fragment spanning residues 614-631, N-terminally acetylated (Ac-RSLKLMATLFSTYASADR; MCE HY-P2464), supplied as the acetate salt. It is the classic pathogenic epitope for the BALB/c mouse model of experimental autoimmune myocarditis (EAM): emulsified in complete Freund's adjuvant (CFA) and injected subcutaneously (typically 150-200 ug/mouse on days 0 and 7), it induces CD4+ T cell-mediated myocardial inflammation, leukocyte infiltration and reduced left ventricular function, peaking around day 21 and progressing toward a dilated-cardiomyopathy (DCM)-like phenotype. Used to study myocarditis immunopathology, Th1/Th17 responses, cardiac remodeling and therapeutic intervention. | Autoimmune myocarditis (EAM), Cardiomyopathy, Cardiac immunology, Animal disease models, Autoimmunity | Mouse MyHC-alpha autoantigen; BALB/c mouse CD4+ T cells (MHC-II restricted) |
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