![CAS 168650-46-2 [Asp371]-Tyrosinase(369-377),human](/uploads/48442/cas-168650-46-2-asp371-tyrosinase-369-377cabb6.jpg)
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| Description | Human tyrosinase 369–377 with position 371 replaced by Asp, used to probe how key residues affect MHC/TCR binding and immunogenicity; used for melanoma structure-activity studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| [Asp371]-Tyrosinase (369-377) human (YMDGTMSQV, HLA-A*0201) | YMDGTMSQV; CAS 168650-46-2; [Asp371]-human tyrosinase 369-377 peptide; Tyr369(D) deamidated epitope | Tumor immunology, Melanoma, Post-translationally modified epitope, MHC-I antigen processing, Autoimmunity/vitiligo, HLA-A*0201 | H-Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val-OH. Residues 369-377 of human tyrosinase (TYR, P14679); the naturally presented form in which Asn371 is post-translationally deamidated to Asp by PNGase deglycosylation (genomic sequence YMNGTMSQV); contains 2 Met + 1 Tyr; light-protected oxidation control. | C42H66N10O16S2 | 1030.41 | 1031.16 | Salt form vendor-dependent (Howei acetate / Ruixi TFA); confirm on order / per COA | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-TYR369-01 | Off-white powder (>=95% purity) | Store at -20°C, dry, sealed, light-protected; 2 Met + Tyr - keep light-protected, deaerated, avoid oxidants. | Short-term storage at 2-8°C, dry and light-protected; avoid repeated freeze-thaw. | Prepare fresh; soluble in aqueous buffer; small fraction of DMSO if needed; store stock in aliquots at -20°C, light-protected. | powder stable for 2-3 years at -20°C, sealed and light-protected. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TYR369-01 | HLA-A*0201 melanoma antigen peptide from human tyrosinase 369-377 (Asn371 deamidated to Asp), a 9-mer. | HLA-A*0201-restricted melanoma tumor-antigen peptide generated by post-translational deamidation of Asn371 to Asp (PNGase-mediated deglycosylation) within human tyrosinase residues 369-377; recognized by autologous CTL and a classic model of retrotranslocation/deglycosylation-dependent MHC-I processing. | Tumor immunology, Melanoma, Post-translationally modified epitope, MHC-I antigen processing, Autoimmunity/vitiligo | Presented on HLA-A*0201 to CD8+ T cells; recognized on human tyrosinase-expressing melanoma cells. |
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