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| Description | Muscle AChR α-subunit residues 97–116 (TFA salt), the immunodominant region recognized by pathogenic MG antibodies/T cells; used for EAMG and immunotherapy. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| AChR alpha (97-116) TFA salt | AChR alpha (97-116) TFA salt, CAS 663154-30-1 (nAChR alpha1 subunit autoepitope peptide) | Autoimmunity, myasthenia gravis, EAMG, autoantigen epitope, AChR, TFA salt | H-Asp-Gly-Asp-Phe-Ala-Ile-Val-Lys-Phe-Thr-Lys-Val-Leu-Leu-Asp-Tyr-Thr-Gly-His-Ile-OH (linear 20-mer, free N-terminal H and C-terminal OH; no Cys) | C106H162N24O30 | 2251.19 | 2252.60 | TFA salt | 20 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-ACHRT-01 | White to off-white powder (TFA salt is hygroscopic - reseal immediately after opening) | Store frozen below -20°C, dry, protected from light and sealed; avoid repeated freeze-thaw; keep TFA salt in a desiccator; contains 1 Tyr - protect from light; stable for ~2 years | Store sealed, dry and protected from light at 4°C, use within 2-4 weeks; after reconstitution, aliquot and store below -20°C | No Cys/Met/Trp; contains one Tyr - keep moderately protected from light; relatively charged (3 Asp, 2 Lys) and hydrophilic - soluble in water or weakly acidic buffer (e.g. dilute acetic acid), sonicate if needed; TFA salt is hygroscopic - use clean dryware for solution preparation | powder is stable for ~2 years below -20°C when dry, protected from light and sealed; TFA salt is hygroscopic - keep away from moisture and store in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ACHRT-01 | 20-aa peptide corresponding to residues 97-116 of the nicotinic acetylcholine receptor alpha1 subunit (DGDFAIVKFTKVLLDYTGHI, CAS 663154-30-1), TFA salt, no Cys; used to induce EAMG and in myasthenia gravis autoimmunity research. | This TFA-salt peptide corresponds to residues 97-116 of the extracellular domain of the muscle-type nicotinic acetylcholine receptor alpha1 subunit (CHRNA1), sequence DGDFAIVKFTKVLLDYTGHI, CAS 663154-30-1. This region is one of the important epitopes recognized by autoreactive T/B cells in myasthenia gravis (MG) patients; the synthetic peptide is used to induce experimental autoimmune myasthenia gravis (EAMG) animal models and to study autoantibody / T-cell responses. Sequence verification confirms the peptide contains no cysteine (Cys) and contains one Tyr (protect from light). | Autoimmune disease, myasthenia gravis (MG), EAMG model, neuromuscular junction, autoantigen epitope | nAChR alpha1 subunit (CHRNA1) |
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