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| Description | PLP residues 178–191, a myelin autoantigen recognized by CD4+ T cells in MS models; used for EAE induction, autoimmune T-cell responses and tolerance therapy. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| PLP (178-191) | PLP178-191; NTWTTCQSIAFPSK; Myelin Proteolipid Protein 178-191; I-A^s encephalitogenic epitope; CAS 172228-98-7 | Myelin proteolipid protein,EAE,multiple sclerosis,CD4 epitope,I-A^s,autoimmune demyelination | H-Asn-Thr-Trp-Thr-Thr-Cys-Gln-Ser-Ile-Ala-Phe-Pro-Ser-Lys-OH (PLP 178-191; identical in mouse/rat/human; I-A^s-restricted encephalitogenic CD4 epitope; contains 1 Cys (pos.6) + 1 Trp - anti-oxidation and light protection required) | C70H106N18O22S | 1582.74 | 1583.78 | Conventional synthetic free peptide , salt form not specified; per supplier COA (synthetic peptides mostly TFA salt) | 14 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-PLP178-01 | White to off-white powder | Store at -20°C or below under inert atmosphere (N2), sealed, dry, light-protected (contains 1 Cys + 1 Trp - anti-oxidation and photo-oxidation protection); aliquot to avoid repeated freeze-thaw | 2–8°C, sealed, dry and light-protected, for days to weeks (short-term transport/storage) | Deoxygenate reconstitution buffer (Cys; prevent disulfide oxidation). Contains hydrophobic aromatic residues (Trp/Phe/Ile); may be poorly soluble in pure water - dissolve first in a small volume of DMSO or dilute acetic acid, then dilute with aqueous buffer. Prepare fresh; aliquot at -20°C; avoid repeated freeze-thaw; protect from light throughout | powder stable for 1-2 years under N2, desiccated, light-protected and sealed; protect from moisture and oxidation; aliquot promptly after opening |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-PLP178-01 | Encephalitogenic PLP 178-191 CD4 epitope (NTWTTCQSIAFPSK), I-A^s-restricted, drives EAE in SJL/J mice. | PLP178-191 is the second potent encephalitogenic CD4+ T-cell epitope identified in SJL/J (H-2^s) mice after PLP139-151; it induces relapsing-remitting experimental autoimmune encephalomyelitis (EAE) and is used to study multiple sclerosis autoimmunity, epitope spreading, antigen-specific T-cell responses and tolerance-based therapies. | Multiple sclerosis,Experimental autoimmune encephalomyelitis (EAE),Autoimmune demyelination,MHC-II CD4 T-cell epitopes,Immune tolerance | Presented by murine MHC class II I-A^s; recognized by PLP-specific CD4+ T-cell receptors |
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