Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of cas 923926-96-9;ova-q4h7peptide in China, also supports custom service. Welcome to wholesale bulk high quality cas 923926-96-9;ova-q4h7peptide from our factory. Contact us for more details.
| Description | A high-affinity analogue of the OVA CD8 epitope SIINFEKL (OVA257-264) with a position-4 Gln→His substitution (Q4H7), strengthening H-2Kb binding and T-cell activation; used for CTL immunity, vaccine affinity maturation and TCR recognition. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| OVA-Q4H7 Peptide (chicken ovalbumin OVA 257-264 Q4H7 variant octamer) | OVA-Q4H7; SIIQFEHL; SIINFEKL Q4H7 variant; OVA 257-264 variant; OT-I low-affinity APL; CAS 923926-96-9 | MHC-I epitope peptide, ovalbumin-derived, H-2Kb-restricted, OT-I TCR, low-affinity APL, thymic positive selection, TCR affinity, CD8+ T cell | H-Ser-Ile-Ile-Gln-Phe-Glu-His-Leu-OH (SIIQFEHL, linear 8-mer free acid). A double-substitution variant of the natural OVA 257-264 epitope SIINFEKL: position 4 Asn(N)->Gln(Q) and position 7 Lys(K)->His(H), giving SIIQFEHL. Relative to the strong agonist N4 (SIINFEKL), Q4H7 is a low-affinity/partial agonist that engages the OT-I TCR more weakly; free C-terminal carboxyl and free N-terminal amine; contains polar Gln/Glu/His, no Met/Cys/Trp. | C46H71N11O13 | 985.52 | 986.14 | Free acid (per published formula C46H71N11O13) | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-OVAQ4H7-01 | White to off-white powder (CAS 923926-96-9) | Store frozen below -20 C, dry, sealed and protected from light; stable approx. 3 years as powder | Store at 2-8 C sealed and dry, use within 2-4 weeks; after reconstitution aliquot and store at -20 C | Moderately water-soluble (polar Gln/Glu/His, no long hydrophobic side chains); reconstitute directly in sterile water or neutral PBS; no Met (no oxidation), no Trp (no photolability), no Cys; for long-term use after reconstitution, aliquot and freeze to avoid repeated freeze-thaw | powder stable long-term (~3 years) at -20 C, dry, sealed and light-protected; no Met/Trp so low oxidation/photodegradation risk; mainly keep moisture-proof |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-OVAQ4H7-01 | OVA-Q4H7 (SIIQFEHL), a low-affinity double-substitution variant (N4->Q, K7->H) of the OVA 257-264 epitope SIINFEKL (CAS 923926-96-9), H-2Kb-restricted, for OT-I transgenic TCR affinity titration, thymic positive selection and CD8+ T-cell activation-threshold studies. | OVA-Q4H7 (SIIQFEHL, CAS 923926-96-9) is an altered peptide ligand (APL) of the chicken ovalbumin (OVA)-derived MHC class I epitope OVA257-264 (SIINFEKL), which is H-2Kb-restricted and recognized by the OT-I TCR in transgenic mice. The native strong agonist is the N4 peptide SIINFEKL; substituting Asn4 with Gln (Q4) and Lys7 with His (H7) yields Q4H7, SIIQFEHL. These replacements reduce the contact strength between peptide-MHC (pMHC) and the OT-I TCR, making Q4H7 a low-affinity, partial agonist: in TAP-deficient OT-I-transgenic mice it drives maturation of CD4-CD8+ thymocytes at low efficiency, and together with the strong agonists N4 (SIINFEKL), Q4 (SIIQFEKL), Q4R7 and T4 it forms a graded TCR-affinity ladder in thymic-selection-intensity experiments. It is widely used to study how the affinity/half-life of the TCR-pMHC interaction sets the outcome of thymic positive vs negative selection, tunes peripheral CD8+ T-cell responsiveness (signal-strength model), and governs T-cell activation thresholds and immunological ignorance. | MHC-I epitope peptides, OT-I TCR affinity studies, thymic positive/negative selection, CD8+ T-cell activation threshold, autoimmunity/tolerance models, signal-strength quantitation | H-2Kb (MHC class I); OT-I T cell receptor (TCR); CD8+ T cells |
Hot Tags: cas 923926-96-9;ova-q4h7peptide, China cas 923926-96-9;ova-q4h7peptide manufacturers, suppliers, factory
