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| Description | NY-ESO-1 (LAGE-1) residues 87–111 (25-mer), covering multiple CD4+/CD8+ epitopes; NY-ESO-1 is aberrantly expressed in many tumors and highly immunogenic, a key target for tumor vaccines and ACT. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| NY-ESO-1 (87-111) pan-MHC class II helper epitope peptide | NY-ESO-1(87-111); CTAG1B peptide; pan-HLA-DR/DP4 epitope | cancer-testis antigen,NY-ESO-1,CD4+ T cells,helper epitope,cancer vaccine,pan-HLA-DR,melanoma | Linear free-acid 25-mer LLEFYLAMPFATPMEAELARRSLAQ (N-term H / C-term OH) | C131H206N32O36S2 | 2867.47 | 2869.39 | TFA salt (per supplier CoA) | 25 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-NYESO-01 | White to off-white powder | Store at -20°C or below, protected from light, dry and sealed (solutions aliquoted at -80°C) | Store at 2-8°C, protected from light and moisture, for 2-4 weeks | Contains 2 oxidation-prone Met residues; prepare fresh. First dissolve in a small volume of DMSO, then dilute with water/buffer; blanket solution with nitrogen or argon, avoid oxidants, protect from light; aliquot and store at -80°C to avoid repeated freeze-thaw | powder is stable; protect from light, keep sealed and dry; equilibrate to room temperature before weighing |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-NYESO-01 | A 25-mer spanning residues 87-111 of the cancer-testis antigen NY-ESO-1; a pan-HLA-DR/DP4-restricted CD4+ helper T-cell epitope used in cancer vaccines and CD4+ T-cell response studies. | NY-ESO-1 (87-111) (LLEFYLAMPFATPMEAELARRSLAQ) is a 25-mer from residues 87-111 of the cancer-testis antigen NY-ESO-1 (CTAG1B). It is a pan-MHC class II-restricted helper T-cell epitope that promiscuously binds multiple HLA-DR (DRB1*0101, 0401, 0701, 1101) and HLA-DP4 (DPB1*0401/0402) molecules, stimulating autologous CD4+ T cells with both Th1-type and Th-2/Th0-type responses. NY-ESO-1 is expressed in melanoma and breast, prostate and lung tumors as well as male germline cells but not in other normal tissues, making it a canonical cancer immunotherapy target. This peptide is used for cancer vaccine design, CD4+ helper T-cell response assays, epitope-specific T-cell line generation and immune monitoring. | Tumor immunology,cancer vaccine,CD4+ T-cell epitopes,melanoma,immune monitoring | Cancer-testis antigen NY-ESO-1/CTAG1B; pan-HLA-DR- and HLA-DP4-restricted CD4+ helper T-cell epitope |
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