CAS 159507-82-1 MOG(92–106),mouse,rat

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CAS 159507-82-1 MOG(92–106),mouse,rat
Details
Myelin oligodendrocyte glycoprotein residues 92-106 (mouse/rat);
Category: MS/EAE autoantigen / MOG epitope.
Peptide Purity (HPLC) ≥95%
CAS No. 159507-82-1
Structure Linear 15-mer (MOG 92-106, mouse/rat)
Solubility Water, dilute acetic acid/PBS
Storage Powder, −20°C, dry, light-protected
Category
Epitope Peptides
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Description

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Description Mouse/rat MOG residues 92–106, a T-cell-recognized region of the myelin-surface glycoprotein; MOG drives demyelination and autoantibody responses in EAE/MS models.

 

Product Basic Information Table

 

Product Standard English Name Product Abbreviation / Alias Function Tags (comma-separated) Core Structure Molecular Formula Exact Mass (Da) Average MW (Da) Salt Form Length (aa)
MOG (92-106), mouse, rat MOG92-106; DEGGYTCFFRDHSYQ; Myelin Oligodendrocyte Glycoprotein 92-106 (mouse/rat, identical in human); I-A^s encephalitogenic epitope; CAS 159507-82-1 Myelin oligodendrocyte glycoprotein,MOG,EAE,MOGAD,CD4 epitope,epitope spreading H-Asp-Glu-Gly-Gly-Tyr-Thr-Cys-Phe-Phe-Arg-Asp-His-Ser-Tyr-Gln-OH (MOG 92-106, mouse/rat, identical in human; I-A^s-restricted 15-mer encephalitogenic CD4 epitope; contains 1 Cys + 2 Tyr - anti-oxidation and light protection required) C80H105N21O27S 1823.72 1824.9 Conventional synthetic free peptide ( MCE HY-P5448), salt form not specified; per supplier COA (synthetic peptides mostly TFA salt) 15

 

Physicochemical Solubility & Storage Parameters

 

Product Code Appearance Long-term Storage Short-term Storage Solution Stability Solid Powder Stability
PEP-MOG92106-01 White to off-white powder Store at -20°C or below under inert atmosphere (N2), sealed, dry, light-protected (contains 1 Cys + 2 Tyr - anti-oxidation and photo-oxidation protection); aliquot to avoid repeated freeze-thaw 2–8°C, sealed, dry and light-protected, for days to weeks (short-term transport/storage) Deoxygenate reconstitution buffer (Cys; prevent disulfide formation / oxidative aggregation). Rich in aromatic residues (2 Phe + 2 Tyr); poorly soluble in pure water - pre-dissolve in a small volume of DMSO or dilute acetic acid, then dilute into aqueous buffer. Prepare fresh; aliquot at -20°C; avoid repeated freeze-thaw; protect from light throughout powder stable for 1-2 years under N2, desiccated, light-protected and sealed; protect from moisture and oxidation; aliquot promptly after opening

 

Functional Description

 

Product Code Frontend Short Summary Detailed Biological Function Description Applicable Research Areas (comma-separated) Targets / Pathways
PEP-MOG92106-01 MOG 92-106 (DEGGYTCFFRDHSYQ), I-A^s-restricted encephalitogenic epitope inducing EAE and epitope spreading in mice. MOG(92-106) mouse/rat is an I-A^s-restricted 15-mer encephalitogenic CD4+ T-cell epitope that induces relapsing-remitting and primary-progressive EAE in SJL/J and A.SW mice, driving broad B-cell epitope spreading to secondary myelin antigens (MBP, PLP). Used in studies of multiple sclerosis, MOG antibody-associated disease (MOGAD), autoimmune demyelination and antigen-specific T/B-cell responses. Multiple sclerosis,Experimental autoimmune encephalomyelitis (EAE),MOG antibody-associated disease (MOGAD),Epitope spreading,MHC-II CD4 T cells Presented by murine MHC class II I-A^s; recognized by MOG-specific CD4+ T cells

 

 

 

 

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