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| Description | MBP residues 83–99 (the human/rat immunodominant encephalitogenic region), inducing EAE; a core peptide for MS T-cell-transfer models and tolerance therapy. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| MBP (83-99) | MBP 83-99; Myelin Basic Protein (83-99); ENPVVHFFKNIVTPRTP; encephalitogenic peptide; MBP encephalitogenic epitope; Myelin Basic Protein (83-99) (bovine) | MBP, autoantigen, EAE, multiple sclerosis, encephalitogenic epitope, MHC-II, HLA-DR2, CD4 T cell, myelin, neuroimmunology | H-Glu-Asn-Pro-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-OH | C93H143N25O24 | 1994.07 | 1995.31 | TFA 盐(商品化产品多标注 trifluoroacetate salt,如 Novachem 4028466-0001) | 17 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MBP83-01 | White to off-white powder (freeze-dried solid) | -20 °C, dry, sealed, protected from light; aliquot recommended | 2–8 °C for short-term transport/storage | Highly basic (contains Arg/Lys/His) and contains Phe; prone to aggregation. Dissolve in water/dilute acid (e.g., dilute acetic acid) or PBS; aliquot and store stock solutions at -20 °C, avoiding repeated freeze-thaw. Peptides for EAE induction are often emulsified in CFA and should be used promptly after emulsification. | Stable as powder; prone to aggregation and degradation upon moisture absorption. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-MBP83-01 | 17-mer of myelin basic protein residues 83–99, a classic encephalitogenic epitope for the EAE model and multiple sclerosis (MS) research. | MBP (83-99) is the immunodominant encephalitogenic epitope of myelin basic protein (MBP); the sequence ENPVVHFFKNIVTPRTP is conserved in bovine/guinea pig/human at this region (the product is designated bovine). It is presented by HLA-DR2 (DRB1*1501) and is one of the major autoantigen epitopes recognized by T cells in multiple sclerosis (MS) patients. In the experimental autoimmune encephalomyelitis (EAE) model, active immunization of Lewis rats/mice with this peptide (or the related guinea-pig MBP 85-99 fragment) induces typical demyelinating disease; it is a core tool peptide for MS immunopathology, T-cell-mediated autoimmunity and drug screening. | Neuroimmunology; multiple sclerosis (MS); experimental autoimmune encephalomyelitis (EAE); autoimmunity; MHC-II (HLA-DR2) antigen presentation; demyelinating diseases | HLA-DR2 (HLA-DRB1*1501, MHC class II); CD4+ T-cell TCR |
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