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| Description | A heterologous mimotope (1040-51) selected on BDC2.5, binding NOD MHC-II I-Ag7 to activate pathogenic Th1 cells; used for type-1-diabetes tolerance, cross-recognition and β-cell destruction. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| BDC2.5 Mimotope 1040-51 (I-Ag7-restricted BDC2.5 T-cell agonist mimotope) | BDC2.5 mimotope 1040-51, H-RVLPLWVRME-OH, 1040-51 mimotope | mimotope, CD4 T cell epitope, I-Ag7 MHC class II, NOD mouse, type 1 diabetes, BDC2.5 T cell clone | RVLPLWVRME (H-Arg-Val-Leu-Pro-Leu-Trp-Val-Arg-Met-Glu-OH, linear 10-mer, free N-terminal amino / free C-terminal carboxyl) | C60H99N17O13S | 1297.73 | 1298.61 | Free acid (per published formula) | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BDC51-01 | white to off-white (MCE, purity ≥95% HPLC) | Store frozen below -20 C, protected from light, dry and tightly sealed | Store at 4 C sealed, dry and light-protected, use within 2-4 weeks; after reconstitution aliquot and store at -20 C | Readily soluble in water (2 Arg, net charge +2, ~50% hydrophobic); contains 1 Met (oxidation-prone) and 1 Trp (light-sensitive); after reconstitution protect from light, deoxygenate, avoid oxidants, aliquot to minimize freeze-thaw cycles | powder stable long-term at -20 C when dry, light-protected and sealed; keep moisture- and light-protected; Met/Trp sensitive, avoid light and oxidation |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-BDC51-01 | 10-mer phage-display mimotope (RVLPLWVRME) for the diabetogenic NOD CD4+ clone BDC2.5, presented by I-Ag7 MHC class II. | BDC2.5 is a diabetogenic CD4+ T-cell clone isolated from non-obese diabetic (NOD) mice that recognizes islet beta-cell antigen(s) in the context of the MHC class II molecule I-Ag7. The 1040-series peptides (including 1040-51, 1040-63=RTRPLWVRME and 1040-31) are high-affinity phage-display mimotopes that do not occur in known beta-cell autoantigens yet potently stimulate BDC2.5 T cells. They are widely used to study type 1 diabetes pathogenesis, epitope identification, antigen-specific tolerance induction (e.g. DEC-205+ dendritic-cell targeting) and TCR-transgenic NOD models. | type 1 diabetes, NOD mouse, autoimmunity, CD4 T cell epitopes, antigen-specific tolerance | MHC class II I-Ag7 (BDC2.5 TCR) |
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