CAS 261172-28-5 UtyHYPeptide(246-254)

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CAS 261172-28-5 UtyHYPeptide(246-254)
Details
Male-specific HY antigen Uty residues 246-254 epitope;
Category: HY minor-histocompatibility antigen / sex-mismatch transplant peptide.
Peptide Purity (HPLC) ≥95%
CAS No. 261172-28-5
Structure Linear 9-mer (Uty HY 246-254)
Solubility Water/PBS
Storage Powder, −20°C, dry, light-protected
Category
Epitope Peptides
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Description

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Description A Y-chromosome Uty-derived HY (male-specific) minor-histocompatibility epitope recognized by female recipients; used for post-allogeneic-HSCT GVL/GVHD and sex-mismatch immune responses.

 

Product Basic Information Table

 

Product Standard English Name Product Abbreviation / Alias Function Tags (comma-separated) Core Structure Molecular Formula Exact Mass (Da) Average MW (Da) Salt Form Length (aa)
Uty H-Y Peptide (246-254), H-2Db-restricted male-specific transplantation antigen peptide Uty HY Peptide 246-254, H-YDb epitope, WMHHNMDLI peptide, UTY male-specific antigen peptide male transplantation antigen, H-Y antigen, MHC class I ligand, H-2Db, CD8 T cell epitope, transplant immunology WMHHNMDLI (H-Trp-Met-His-His-Asn-Met-Asp-Leu-Ile-OH, linear 9-mer, free N-terminal amino / free C-terminal carboxyl) C53H77N15O13S2 1195.53 1196.41 Free acid 9

 

Physicochemical Solubility & Storage Parameters

 

Product Code Appearance Long-term Storage Short-term Storage Solution Stability Solid Powder Stability
PEP-UTYHY-01 white to off-white (GenScript, purity ≥95% HPLC) Store frozen below -20 C, protected from light, dry and tightly sealed Store at 4 C sealed, dry and light-protected, use within 2-4 weeks; after reconstitution aliquot and store at -20 C, avoid repeated freeze-thaw Moderately soluble in water (~44% hydrophobic); contains 2 Met (oxidation-prone) and 1 Trp (light-sensitive); dissolve in a small amount of DMSO then dilute with water/PBS; protect from light and deoxygenate after reconstitution, aliquot for storage powder stable long-term at -20 C when dry, light-protected and sealed; keep moisture- and light-protected; Met is oxidation-sensitive, avoid prolonged air exposure

 

Functional Description

 

Product Code Frontend Short Summary Detailed Biological Function Description Applicable Research Areas (comma-separated) Targets / Receptors
PEP-UTYHY-01 9-mer Y-chromosomal Uty H-Y male transplantation epitope (residues 246-254, WMHHNMDLI) presented by mouse H-2Db. This 9-mer spans residues 246-254 of the Y-chromosomal UTY protein and is the prototypical male-specific (H-Y) minor histocompatibility epitope, presented by the mouse MHC class I molecule H-2Db. Female H-2b CD8+ T cells recognize this Y-encoded peptide and reject male skin or organ grafts; it is a classic reagent for studying sex-mismatched graft rejection, minor histocompatibility antigens, antitumor T-cell responses and post-allogeneic stem-cell transplantation immunity. transplant immunology, H-Y minor histocompatibility antigen, CD8 T cells, sex-mismatched transplantation, mouse models Mouse H-2Db MHC class I (male-specific CD8+ T cells)

 

 

 

 

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