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| Description | Rat/mouse MOG residues 40–54, a second T-cell epitope region besides the canonical 35-55; used for EAE/MogAD epitope hierarchy and demyelination. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse | MOG (40-54) rat/mouse, YRSPFSRVVHLYRNG, CAS 507233-87-6, within encephalitogenic MOG 35-55 | MOG, myelin oligodendrocyte glycoprotein, EAE autoantigen, multiple sclerosis, T-cell epitope, neuroautoimmunity | H-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-OH (15-aa linear peptide, free N-term/C-term; mouse/rat MOG residues 40-54; no Cys/Met/Trp; 2 Tyr; net charge +4: 3 Arg + 1 His) | C84H127N27O21 | 1849.97 | 1851.11 | TFA salt (typical) | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MOG4054-01 | White to off-white powder (standard synthetic peptide) | Store frozen below -20°C, dry, sealed and protected from light (2-3 years); contains 2 Tyr - protect from light (amber vial/foil); keep desiccated and avoid repeated freeze-thaw | Store sealed and desiccated at 2-8°C protected from light, use within 2-4 weeks; after reconstitution, aliquot and store at -20°C protected from light | Net charge +4 (3 Arg, 1 His, no acidic residues) - highly hydrophilic and readily soluble in water/neutral buffer; contains 2 Tyr (light-sensitive) - protect from light during handling and storage; MOG peptides show some aggregation tendency - use promptly after reconstitution, aliquot into single-use portions and avoid repeated freeze-thaw | powder stable for 2-3 years at -20°C when dry, sealed and protected from light; keep away from moisture and light; aliquot promptly after opening and store in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-MOG4054-01 | 15-aa peptide corresponding to mouse/rat myelin oligodendrocyte glycoprotein (MOG) residues 40-54 (sequence YRSPFSRVVHLYRNG, CAS 507233-87-6), lying within the classic encephalitogenic epitope 35-55; used for EAE models and MOG-specific T-cell epitope studies. | Myelin oligodendrocyte glycoprotein (MOG) is a minor myelin glycoprotein expressed on the oligodendrocyte surface at the outermost layer of CNS myelin, and a key pathogenic autoantigen in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). This product corresponds to mouse/rat MOG residues 40-54 (YRSPFSRVVHLYRNG), lying within the classic encephalitogenic epitope MOG 35-55 (MEVGWYRSPFSRVVHLYRNGK, CAS 149635-73-4) and derived from it under the same protein numbering; relative to MOG 35-55 it removes the N-terminal Met-Glu-Val-Gly-Trp (35-39) and the C-terminal Lys (55). It is used for EAE induction and disease-course studies, detection of MOG-specific CD4+ T cells (ELISpot / proliferation / intracellular cytokine staining), and studies of MOG peptide-MHC-II and TCR recognition. Suppliers (TargetMol / AdooQ / Immunomart) list CAS 507233-87-6 and formula C84H127N27O21. | EAE model, multiple sclerosis, neuroimmunology, MOG autoantigen, CD4+ T-cell detection, autoimmune encephalomyelitis | MHC-II-restricted MOG epitope presentation; T-cell receptor (TCR); pathogenic MOG-specific CD4+ T cells |
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