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| Description | TYVPANASL binds the corresponding MHC-I and is specifically recognized by TCRs; used for epitope-specific T-cell monitoring, MHC-tetramer production and recognition-mechanism studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| TYVPANASL | TYVPANASL, HER2/neu (66-74), neu p66 CTL epitope | HER2/neu epitope peptide, H-2d restricted CTL epitope, CD8+ T cell epitope, Cancer vaccine | TYVPANASL (H-Thr-Tyr-Val-Pro-Ala-Asn-Ala-Ser-Leu-OH, linear 9-mer) | C42H66N10O14 | 934.48 | 935.05 | TFA salt (typical) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-TYVPANASL-01 | white to off-white powder (typical form of synthetic epitope peptides; appearance not separately published on this SKU page) | Store frozen below -20°C, protected from light, in a dry and sealed container; stable for 3 years as powder at -20°C (TargetMol); keep away from moisture; shipped on blue ice or at ambient temperature | Store sealed and dry at 4°C, use within 2-4 weeks; after reconstitution, aliquot into single-use portions and freeze below -20°C, avoid repeated freeze-thaw cycles | Moderately hydrophobic (56% hydrophobic residues); reconstitute in water or acidic buffer, using a small amount of DMSO as a cosolvent if needed and then diluting with water; solution is stable for 1 year at -80°C (TargetMol); contains 1 Tyr residue, so keep reconstituted solution protected from light to avoid photo-oxidation | powder is stable for 3 years at -20°C (TargetMol); keep moisture-proof and sealed; contains a Tyr residue, so keep the solid protected from light as well |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TYVPANASL-01 | The minimal CTL epitope TYVPANASL (aa 66-74) from HER2/neu, an H-2d (BALB/c mouse) MHC-I-restricted CD8+ T cell epitope used in J-HER/J-LEAPS cancer vaccine development. | TYVPANASL derives from HER2/neu (the neu proto-oncoprotein used in the rat BALB/c tumor model). It is the minimal CD8+ T cell (CTL) epitope at aa 66-74 and is an MHC-I (H-2d)-restricted epitope. Literature confirms it as the core CTL-eliciting epitope of the J-HER/J-LEAPS cancer vaccine ("J-HER incorporates a prominent CTL eliciting minimal epitope (aa 66-74: TYVPANASL) for BALB/c mice"). The peptide stimulates H-2d-restricted CD8+ T cell responses and is used in HER2-positive cancer immunotherapy vaccine development and tumor immunity mechanism studies. | Tumor immunology, CD8+ T cell detection, Cancer vaccine development, MHC-I epitope identification | MHC-I (presented by H-2d); CD8+ T cell receptor (TCR) |
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