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| Description | The C-terminal active fragment of frog GRP 20–29, corresponding to the bombesin-like C-terminal core; used for neuroendocrine signaling, itch and GRP receptor pharmacology. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) | |
| GRP (20-29), frog | frog GRP (20-29), [Ser2]-Neuromedin C, GSHWAVGHLM-NH2, CAS 136058-54-3, Xenopus laevis GRP active fragment | gastrin-releasing peptide, GRPR agonist, bombesin-like peptide, neuropeptide, tumor microenvironment, pain modulation, C-terminal amidated peptide | H-Gly-Ser-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2 (GSHWAVGHLM-NH2, linear 10-mer, C-terminal amidated; contains 1 Trp, 1 Met, 2 His; no Cys) | C49H72N16O11S | 1092.53 | 1093.27 | TFA salt (typical) | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRP-01 | White to off-white powder | Store frozen below -20°C, dry, protected from light, sealed; avoid repeated freeze-thaw; contains 1 Met (oxidation-sensitive) and 1 Trp (light-sensitive) - keep dry and dark; powder stable for 2-3 years at -20°C | Store sealed, dry and protected from light at 4°C, use within 2-4 weeks; after reconstitution aliquot into single-use portions and store below -20°C, avoid repeated freeze-thaw | Amphipathic bombesin-like C-terminal decapeptide (hydrophobic Trp/Leu/Val/Ala, weakly basic 2 His); limited direct water solubility; first wet with a small amount of DMSO or sterile water, then dilute with PBS (pH 7.4) or weakly acidic buffer (e.g. 10% acetic acid) to working concentration; Met is oxidation-sensitive - avoid oxidizing/reducing agents; Trp is light-sensitive - protect from light; use promptly after reconstitution | powder stable for 2-3 years at -20°C when dry, protected from light and sealed; TFA salt is hygroscopic - protect from moisture, aliquot promptly after opening and keep in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRP-01 | 10-mer frog gastrin-releasing peptide GRP (20-29) (GSHWAVGHLM-NH2, CAS 136058-54-3, a.k.a. [Ser2]-Neuromedin C), a natural GRPR agonist fragment for neuropeptide signaling, pain and tumor microenvironment research. | Frog gastrin-releasing peptide (GRP) belongs to the bombesin-like peptide family and is homologous to human GRP/neuromedin C. Its C-terminal decapeptide GSHWAVGHLM-NH2 (a.k.a. [Ser2]-Neuromedin C, CAS 136058-54-3) retains the key C-terminal heptapeptide amidated motif (Trp-Ala-Val-Gly-His-Leu-Met-NH2) required for binding the GRP receptor (BB2/GRPR). GRP/GRPR signaling regulates gastrointestinal hormone secretion, growth-hormone release, central pain transmission and stress responses, and drives proliferation and migration in solid tumors such as lung and prostate cancer. This C-terminally amidated short peptide is used for GRPR agonist/antagonist activity assays, intracellular calcium / MAPK-PI3K-Akt pathway studies, and structure-relationship studies of GRPR-targeted probes. Sequence cross-confirmed by chemBlink (CAS name Gly-Ser-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2), Solarbio, QYAOBIO and PeptideDb. | neuropeptide signaling, GRPR pharmacology, pain modulation, gastrointestinal physiology, tumor proliferation/migration, tumor microenvironment, bombesin receptor research | GRP receptor / BB2 (GRPR); bombesin receptor family |
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