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| Description | Beacon (a neuroendocrine protein related to agouti/agouti-related signaling) residues 47–73; involved in hypothalamic energy metabolism/stress; used for neuroendocrine and metabolic research. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Beacon (47-73) | Beacon (47-73); UBL5 47-73; WYTIFKDHVSLGDYEIHDGMNLELYYQ; hypothalamic energy-regulating peptide; CAS 681153-68-4 | Energy balance and feeding regulation,Metabolic syndrome,Adrenocortical endocrinology,Obesity research,UBL5/Beacon neuroendocrinology | H-Trp-Tyr-Thr-Ile-Phe-Lys-Asp-His-Val-Ser-Leu-Gly-Asp-Tyr-Glu-Ile-His-Asp-Gly-Met-Asn-Leu-Glu-Leu-Tyr-Tyr-Gln-OH; C-terminal residues 47-73 of Beacon/UBL5 (ubiquitin-like protein 5, a 73-aa hypothalamic energy-regulating peptide); linear peptide with free N-terminal amine / free C-terminal carboxyl; contains 1 Trp + 4 Tyr + 1 Met-keep fully light-protected and prevent oxidation. | C156H217N35O46S | 3348.54 | 3350.71 | free powder (TFA / acetate available on request) | 27 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BEACON-01 | White to off-white powder (may appear pale yellow due to Trp/Tyr). | -20°C, dry and sealed; contains 1 Trp + 4 Tyr + 1 Met-keep fully light-protected (amber foil/vial) and deoxygenated to prevent oxidation; avoid repeated freeze-thaw. | 2-8°C, light-protected; use within 1 week. | Moderately hydrophobic, soluble in water/buffer; many aromatic residues (W + 4Y)-protect from light and watch for aggregation; reconstitute gently and prepare fresh; store stock in light-protected aliquots at -20°C. | powder is stable ~1-2 years at -20°C dry and light-protected; contains Met-protect from oxidation. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BEACON-01 | Beacon (UBL5) C-terminal 47-73 27-mer WYTIFKDHVSLGDYEIHDGMNLELYYQ for energy-balance/endocrine metabolism research. | Hypothalamic Beacon/UBL5 expression correlates positively with body-fat percentage, and intracerebroventricular Beacon infusion dose-dependently increases food intake and body weight, regulating energy balance and the metabolic syndrome. Beacon (47-73) inhibits glucocorticoid (corticosterone/cortisol) secretion and proliferation of cultured rat/human adrenocortical zona fasciculata/reticularis cells in vitro, and lowers plasma ACTH, aldosterone and corticosterone in rats in vivo. | Energy balance and feeding regulation,Metabolic syndrome,Adrenocortical endocrinology,Obesity research,UBL5/Beacon neuroendocrinology | Adrenocortical zona fasciculata/reticularis cells; hypothalamic feeding/energy-balance pathways |
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