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| Description | The pre-S1 segment binding the hepatocyte receptor NTCP (sodium taurocholate co-transporting polypeptide), mediating viral attachment and entry; used for HBV entry, NTCP interaction and liver-targeted delivery. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Hepatitis B Virus Receptor Binding Fragment (preS1 21-47) | HBV receptor binding fragment, HBV peptide 4980, PLGFFPDHQLDPAFGANSNNPDWDFNP, HBV preS1 21-47 | HBV preS1 receptor-binding peptide, viral entry research, hepatocyte binding, NTCP receptor, immunogen | H-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-OH (PLGFFPDHQLDPAFGANSNNPDWDFNP, linear 27-mer, free termini) | C140H185N35O42 | 3028.34 | 3030.22 | Free acid (salt-free) | 27 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-HBVRB-01 | white to off-white powder | Store desiccated and sealed below -20°C, protected from light; powder stable for 2-3 years; reconstituted aliquots can be stored at -80°C for ~1 year | Store sealed and desiccated at 4°C, use within 2-4 weeks; after reconstitution, aliquot and store at -20°C, avoid repeated freeze-thaw | Moderately hydrophobic viral peptide (~52% hydrophobic residues); net charge -3 (4 Asp + 1 His), negative charge aids aqueous solubility; contains 1 Trp requiring light protection; dissolve first in a small volume of DMSO then dilute with PBS, or dissolve directly in slightly alkaline aqueous buffer; no Cys/Met, no strong oxidation sensitivity | powder stable for 2-3 years at -20°C when desiccated and sealed; protect from moisture and light; aliquot promptly after opening and keep in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-HBVRB-01 | The HBV receptor-binding fragment (preS1 21-47, PLGFFPDHQLDPAFGANSNNPDWDFNP) is the N-terminal segment of the HBV large envelope protein preS1 responsible for hepatocyte recognition; it specifically binds HepG2 cells and is used in HBV entry and neutralizing antibody research. | The HBV Receptor Binding Fragment (commercial name hepatitis B peptide 4980) corresponds to residues 21-47 of the preS1 domain of the HBV large envelope protein LHBs (PLGFFPDHQLDPAFGANSNNPDWDFNP). Neurath et al. first identified this fragment as the host hepatocyte receptor-binding site in Cell (1986); this synthetic peptide specifically binds HepG2 human hepatoma cells and is a candidate immunogen based on the attachment-blockade pathway of virus neutralization. Subsequent work established that the N-terminal preS1 region (especially residues 2-48, N-myristoylated) mediates HBV/HDV entry through interaction with the hepatocyte surface bile acid transporter sodium taurocholate cotransporting polypeptide (NTCP/SLC10A1). This peptide is widely used for HBV entry mechanism studies, NTCP interaction assays, neutralizing antibody epitope mapping, and prophylactic vaccine research. CAS registry number 114495-85-1. | Hepatitis B entry mechanism, NTCP receptor research, virus neutralizing antibodies, prophylactic vaccines, hepatocyte biology | Hepatocyte surface receptors (HepG2 cell binding); sodium taurocholate cotransporting polypeptide NTCP (SLC10A1), the preS1 functional receptor |
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