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| Description | A 17-aa peptide designed from ERα sequence to mimic/perturb ERα signaling; used for estrogen signaling and breast/reproductive biology research. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| ERα17p (human estrogen receptor alpha ERα residues 295-311; PLMIKRSKKNSLALSLT, 17-mer; free acid; CAS 938077-77-1) | ERα17p; ERα (295-311); PLMIKRSKKNSLALSLT; human ERα hinge/AF2 17-mer; GPER inverse agonist; calmodulin-binding peptide | Breast cancer, estrogen receptor alpha ERα, GPER (GPR30), inverse agonist, antiproliferative peptide, calmodulin-binding, anticancer peptide | H-Pro-Leu-Met-Ile-Lys-Arg-Ser-Lys-Lys-Asn-Ser-Leu-Ala-Leu-Ser-Leu-Thr-OH (PLMIKRSKKNSLALSLT), linear free-acid 17-mer (N-term H, C-term OH); derived from the hinge/ligand-binding AF2 region (residues 295-311) of human estrogen receptor alpha (ERα/ESR1, UniProt P03372), corresponding to residues 123-139 of the ERα36 isoform; contains one Met (oxidation-sensitive) and is basic (3×Lys + 1×Arg); no Cys/Trp/Tyr. The N-terminal PLMI tetrapeptide is the core GPER-binding motif | C84H154N24O23S | 1899.13 | 1900.35 | TFA salt (standard synthetic-peptide counterion; per supplier COA) | 17 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-ERA17P-01 | White to off-white powder | Store below -20°C, dry, sealed and flushed with argon/nitrogen (inert gas). Because it contains Met, protect against oxidation: deoxygenate, avoid oxidants and minimize repeated opening. As a hygroscopic TFA salt, open, weigh quickly and reseal over a desiccator; aliquot into single-use portions and avoid repeated freeze-thaw. | Short-term storage at 2-8°C under inert gas, sealed and dry for ~2 weeks; prepare working solutions fresh; use at 4°C short-term or aliquot and store at -20°C under inert gas. | Basic peptide (3×Lys + Arg + N-terminus), readily soluble in water or slightly acidic buffer. Met-containing solutions are oxidation-prone: avoid contact with oxidants and use deoxygenated solvent. No Trp/Tyr, so no special light protection required; prepare stock fresh, aliquot and store deoxygenated; never repeatedly freeze-thaw. | No free Cys (no disulfide formation); Met-containing solid stable ~2 years at -20°C, sealed and dry, ideally under argon. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-ERA17P-01 | A 17-mer (PLMIKRSKKNSLALSLT) from human ERα residues 295-311 acting as a GPER (GPR30) inverse agonist that exerts antiproliferative/pro-apoptotic effects in breast cancer cells, with additional anti-inflammatory and anti-hyperalgesic activity. | ERα17p (PLMIKRSKKNSLALSLT) is a synthetic 17-mer corresponding to residues 295-311 of the hinge/AF2 domain of human estrogen receptor alpha (ERα/ESR1, UniProt P03372; residues 123-139 of the ERα36 isoform). It was originally synthesized as an ERα calmodulin (CaM)-binding-site peptide and later identified as an inverse agonist of the membrane estrogen receptor GPER (GPR30). Studies (Mol Oncol. 2013;7(4):825-836; Cells. 2020;9(2):447; Front Endocrinol. 2021;12:578250) show that, via a GPER-dependent mechanism, it inhibits proliferation and induces apoptosis/necrosis in breast cancer cells (MCF-7, SK-BR-3, T47D, MDA-MB-231) and reduces xenografted human breast tumor growth; its N-terminal PLMI tetrapeptide is the core GPER-binding motif. In mice, it also exerts GPER-dependent anti-hyperalgesic and anti-inflammatory effects in CFA/carrageenan inflammation models. It is used in breast-cancer estrogen signaling, GPER drug discovery and ERα structure-function studies. CAS 938077-77-1 is consistent across suppliers (MedChemExpress, TargetMol, AdooQ) with sequence PLMIKRSKKNSLALSLT and formula C84H154N24O23S. | Breast cancer research, estrogen signaling, GPER (GPR30) drug discovery, anticancer peptides, antiproliferative/apoptosis studies, anti-inflammatory and analgesic research | GPER (GPR30) membrane estrogen receptor (inverse agonism); human ERα residues 295-311 calmodulin-binding site |
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