GluN1(359-378)

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GluN1(359-378)
Details
NMDA receptor GluN1 subunit residues 359-378;
Category: Neuroreceptor-derived peptide / NMDAR research.
Peptide Purity (HPLC) ≥95%
Structure Linear 20-mer (GluN1/NR1 359-378)
Solubility Dilute acetic acid, DMSO cosolvent, PBS
Storage Powder, −20°C, dry, light-protected
Category
Epitope Peptides
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Description

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Description The core 20-mer within GluN1 356–385; used for fine epitope mapping of anti-NMDAR encephalitis autoantibodies.

 

Product Basic Information Table

 

Product Standard English Name Product Abbreviation / Alias Function Tags (comma-separated) Core Structure Molecular Formula Exact Mass (Da) Average MW (Da) Salt Form Length (aa)
GluN1 (359-378) human NMDAR GluN1 (GRIN1/Q05586) residues 359-378 20-mer, sub-region of 356-385, anti-NMDAR encephalitis epitope NMDAR, GluN1/GRIN1, anti-NMDAR encephalitis, autoantigen epitope, fine epitope mapping, N-terminal domain (NTD) H-Arg-Lys-Leu-Val-Gln-Val-Gly-Ile-Tyr-Asn-Gly-Thr-His-Val-Ile-Pro-Asn-Asp-Arg-Lys-OH (RKLVQVGIYNGTHVIPNDRK, linear 20-mer, residues 359-378 of UniProt Q05586 isoform 1 full-length numbering; central sub-region of the 30-mer 356-385; contains 1 Tyr, 1 Arg, 2 Lys, 1 His; no Cys/Met/Trp) C102H171N33O28 2306.30 2307.68 TFA salt (typical) 20

 

Physicochemical Solubility & Storage Parameters

 

Product Code Appearance Long-term Storage Short-term Storage Solution Stability Solid Powder Stability
PEP-GLUN1B-01 White to off-white powder Store frozen below -20°C, dry, sealed and protected from light; avoid repeated freeze-thaw; contains 1 Tyr (light-sensitive) - protect from light; powder stable for 2-3 years at -20°C Store sealed, dry and protected from light at 4°C, use within 2-4 weeks; after reconstitution aliquot into single-use portions and store at -20°C, avoid repeated freeze-thaw Relatively hydrophilic (1 Arg, 2 Lys positive; 1 Asp negative; polar Gly/Thr/Asn); soluble in sterile water or PBS (pH 7.4), dilute acetic acid if needed; contains 1 Tyr (light-sensitive) - protect from light; after reconstitution aliquot into single-use portions and avoid repeated freeze-thaw powder stable for 2-3 years at -20°C when dry, protected from light and sealed; TFA salt is hygroscopic - protect from moisture, aliquot promptly after opening and keep in a desiccator

 

Functional Description

 

Product Code Frontend Short Summary Detailed Biological Function Description Applicable Research Areas (comma-separated) Targets / Pathways
PEP-GLUN1B-01 20-mer corresponding to residues 359-378 of human NMDAR GluN1 (GRIN1, Q05586) (RKLVQVGIYNGTHVIPNDRK), the central sub-region of the 356-385 30-mer, used for fine epitope mapping in anti-NMDAR encephalitis. This peptide corresponds to residues 359-378 of the human NMDAR GluN1 subunit (GRIN1, UniProt Q05586 isoform 1, 938 aa full length), sequence RKLVQVGIYNGTHVIPNDRK, numbered on the same UniProt full-length system; it is the central sub-region (positions 4-23) of the GluN1 (356-385) 30-mer (LQNRKLVQVGIYNGTHVIPNDRKIIWPGGE), and the two products share one numbering system with consistent overlap. This 20-mer also lies in the extracellular N-terminal domain of GluN1 and is used for fine mapping and truncation analysis of anti-NMDAR encephalitis autoantibody epitopes to define the shortest core recognition motif. Sequence confirmed by MCE catalog (MCE: Arg-Lys-Leu-Val-Gln-Val-Gly-Ile-Tyr-Asn-Gly-Thr-His-Val-Ile-Pro-Asn-Asp-Arg-Lys). No Cys/Met/Trp; contains 1 Tyr - protect from light. anti-NMDAR encephalitis, autoimmune encephalitis, fine epitope mapping, autoantibody detection, NMDAR structure-function, neuroimmunology NMDAR GluN1 subunit (GRIN1/Q05586) N-terminal domain; anti-GluN1 autoantibodies

 

 

 

 

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