IRGRILHDGAYSLTLQGLGIHTFA

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IRGRILHDGAYSLTLQGLGIHTFA
Details
20-mer IRGRILHDGAYSLTLQGLGIH, TFA salt;
Category: Long-peptide epitope / T-cell peptide.
Peptide Purity (HPLC) ≥95%
Counter-ion TFA
Structure Linear 20-mer (IRGRILHDGAYSLTLQGLGIH, TFA salt)
Solubility Water cosolvent, DMSO/PBS
Storage Powder, −20°C, dry, light-protected
Category
Epitope Peptides
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Description

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Description IRGRILHDGAYSLTLQGLGIH (TFA salt), hydrophobic and covering multiple overlapping T epitopes; used for long-peptide immune monitoring, MHC binding and T-cell assays.

 

Product Basic Information Table

 

Product Standard English Name Product Abbreviation / Alias Function Tags (comma-separated) Core Structure Molecular Formula Exact Mass (Da) Average MW (Da) Salt Form Length (aa)
IRGRILHDGAYSLTLQGLGIH TFA salt (rat HER2/neu class II MHC multi-epitope peptide; CAS 1443436-79-0) IRGRILHDGAYSLTLQGLGIH TFA, rat HER2/neu class II peptide TFA salt, class II HER2-DC1 vaccine peptide, PEP-HER2IITF-01 T-cell epitope, MHC class II, CD4 T cell, cancer vaccine, HER2 immunotherapy, dendritic cell vaccine, TFA salt hygroscopic IRGRILHDGAYSLTLQGLGIH (H-Ile-Arg-Gly-Arg-Ile-Leu-His-Asp-Gly-Ala-Tyr-Ser-Leu-Thr-Leu-Gln-Gly-Leu-Gly-Ile-His-OH, linear 21-mer, free N-terminal amino / free C-terminal carboxyl, supplied as the trifluoroacetate (TFA) salt) C102H168N32O28 2289.27 2290.66 TFA salt (trifluoroacetate; more hygroscopic than the free-acid peptide) 21

 

Physicochemical Solubility & Storage Parameters

 

Product Code Appearance Long-term Storage Short-term Storage Solution Stability Solid Powder Stability
PEP-HER2IITF-01 white to off-white (MCE, purity ≥95% HPLC; trifluoroacetate/TFA salt, hygroscopic) Store frozen below -20°C, protected from light, dry and tightly sealed (with desiccant); the TFA salt is hygroscopic-keep moisture out Store at 4°C sealed, dry and light-protected, use within 2-4 weeks (TFA salt absorbs moisture-recap promptly and keep with desiccant); after reconstitution aliquot and store at -20°C, avoid repeated freeze-thaw Moderately soluble in water (21-mer, ~38% hydrophobic); contains 1 Tyr (light-sensitive), no Cys/Met; reconstitute in sterile water or PBS with sonication if needed; protect from light and aliquot for storage powder stable long-term at -20°C when dry, light-protected and sealed; keep moisture- and light-protected. This product is the TFA salt and is relatively hygroscopic-weigh quickly after opening, immediately reseal with desiccant and keep light-protected; if equilibrating to room temperature, do so in a desiccator to avoid moisture uptake.

 

Functional Description

 

Product Code Frontend Short Summary Detailed Biological Function Description Applicable Research Areas (comma-separated) Targets / Pathways
PEP-HER2IITF-01 A multi-epitope MHC class II peptide derived from rat HER2/neu (TFA salt), used in HER2-DC1 dendritic-cell cancer-vaccine and CD4 T-cell studies. IRGRILHDGAYSLTLQGLGIH is a multi-epitope MHC class II (CD4) peptide derived from the rat HER2/neu oncoprotein. It is loaded onto dendritic cells (DC1) to generate HER2 vaccines, eliciting CD4 T-cell responses in HER2-positive mammary carcinoma models and synergizing with sequential anti-PD-1 therapy to improve survival. It is used in tumor immunotherapy and epitope-vaccine design. Tumor immunology, cancer vaccine, dendritic cell vaccine, MHC class II epitope, HER2-targeted therapy, immunotherapy MHC class II (CD4 T-cell recognition; rat HER2/neu)

 

 

 

 

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