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| Product name | CAS:606968-52-9;FC131 |
| Sequence | |
| Three letter sequence | |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C36H47N11O6 |
| Molecular weight (Da) | 729.83 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| FC131 | #FC131; CAS 606968-52-9; CXCR4 cyclic peptide antagonist; SDF-1 blocking peptide; Chemokine receptor inhibitory peptide | Highly selective CXCR4 chemokine receptor antagonist, SDF-1/CXCR4 axis blockade, Tumor metastasis suppression, Stem cell migration regulation, HIV entry inhibition, Immune cell chemotaxis, GPCR peptide inhibitor, Inflammatory chemokine pathway | Acetyl-Cys-Phe-Phe-Arg-CycloLeu-Thr-Trp-Cys-amide, intramolecular disulfide bridge between Cys1 & Cys9 | C₅₆H₇₆N₁₆O₁₁S₂ | 1212.54 | 1213.41 | Acetylation (Ac-) | C-terminal amidation (-NH₂) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-FC131 | White powder | -20°C, sealed and light-proof, aliquot to avoid repeated freeze-thaw | 2~8°C, use within 1 month, prepare fresh and sterile-filter with 0.22μm membrane | Stable for 48 h at 4°C | Stable for 3 years at -20°C |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-FC131 | FC131 is a highly selective cyclic peptide CXCR4 antagonist, potently blocks endogenous ligand SDF-1 binding, suppresses tumor metastasis, stem cell homing and HIV gp120-mediated viral entry, canonical tool antagonist for chemokine pathway research | FC131 is an engineered 9-amino-acid cyclic peptide incorporating unnatural cycloleucine residue. Dual terminal modification (N-acetylation + C-amidation) combined with intramolecular disulfide bond drastically enhances peptidase resistance and CXCR4 subtype selectivity, with nanomolar binding affinity to CXCR4 and negligible off-target binding to CXCR1/CXCR2/CXCR7. Core biological activities: 1. Chemokine axis blockade: Competitively inhibits SDF-1α binding to CXCR4, fully abrogates chemotactic migration of immune cells, tumor cells and hematopoietic stem cells; 2. Oncological research: Blocks tumor cell invasion and distant metastasis for solid tumor metastasis & tumor microenvironment models; 3. Antiviral application: Prevents HIV gp120 co-receptor engagement with CXCR4 to suppress entry of X4-tropic HIV strains; 4. Stem cell & inflammation regulation: Modulates hematopoietic stem cell homing and attenuates inflammatory immune cell infiltration in autoimmune disorders. Widely applied in tumor metastasis pharmacology, chemokine GPCR research, HIV virology, stem cell biology, immune inflammation and targeted peptide drug screening | Tumor metastasis pharmacology, Chemokine GPCR research, HIV viral entry mechanism, Hematopoietic stem cell homing, Immune inflammatory regulation, Autoimmune disease models, Peptide antagonist drug development | Chemokine Receptor CXCR4 (highly selective); No significant cross-reactivity with CXCR1, CXCR2, CXCR7 |
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