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| Product name | CAS:212370-59-7;HS024 |
| Sequence | Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9) |
| Three letter sequence | |
| Peptide purity (HPLC, %) | 95%/99% |
| Molecular formula | C58H79N19O10S2 |
| Molecular weight (Da) | 1266.5 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Amino Acid Full Name Sequence | Molecular Formula | Exact Molecular Weight (Da) | Average Molecular Weight (Da) | Terminal Modification - N-terminus | Terminal Modification - C-terminus | Sequence Length (aa) |
| HS024 | #HS024; CAS 212370-59-7; Selective MC4R cyclic antagonist; Food intake stimulating peptide; Melanocortin receptor blocking peptide | Highly selective MC4 receptor antagonist, Feeding behavior stimulation, Melanocortin pathway blockade, Metabolic obesity model, Antagonize MT-II / α-MSH cardiovascular effects, GPCR peptide inhibitor, Appetite regulation research | Acetyl-Cys-Nle-Arg-His-D-2Nal-Arg-Trp-Gly-Cys-amide, Intramolecular disulfide bridge between Cys1 & Cys9 | C₅₈H₇₉N₁₉O₁₀S₂ | 1265.52 | 1266.52 | Acetylation (Ac-) | C-terminal amidation (-NH₂) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-HS024 | White powder | -20°C, sealed and light-proof, aliquot to avoid repeated freeze-thaw | 2~8°C, use within 1 month, prepare fresh and sterile-filter with 0.22μm membrane | Stable for 48 h at 4°C | Stable for 3 years at -20°C |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Target / Receptor |
| PEP-HS024 | HS024 is a highly selective cyclic peptide MC4 receptor antagonist, powerfully blocks central melanocortin pathway to boost food intake, fully reverses hypotension & bradycardia induced by Melanotan II / α-MSH, core tool antagonist for appetite & metabolic pathway research | HS024 is a 9-amino-acid engineered cyclic peptide incorporating unnatural residues D-2-naphthylalanine and Norleucine. Dual terminal modification (N-acetylation + C-amidation) plus intramolecular disulfide bond drastically enhance peptidase resistance and receptor subtype selectivity. Receptor affinity ranking: MC4R (Ki=0.29 nM) >> MC5R > MC3R >> MC1R, with superior MC4 subtype selectivity versus other melanocortin antagonists. Core bioactivities: 1. Central appetite modulation: Intracerebroventricular administration specifically blocks anorexic MC4 signaling in hypothalamus to robustly increase food consumption in mice/rats, applied for anorexia, cachexia and energy metabolism models; 2. Cardiovascular pathway antagonism: Completely counteracts hypotension and bradycardia triggered by α-MSH or Melanotan II, ideal tool to validate melanocortin cardiovascular physiology; 3. Metabolic GPCR research reagent: Serves as exclusive negative control for MC4R, widely used in obesity, energy expenditure, hypothalamic feeding circuit and melanocortin SAR screening. Widely applied in neuroendocrinology, feeding behavior science, metabolic obesity pharmacology, melanocortin GPCR research, cardiovascular peptide regulation and anorexia disease models | Neuroendocrinology, Feeding behavior regulation, Metabolic obesity pharmacology, Melanocortin GPCR research, Cardiovascular physiological mechanism, Anorexia disease model, Peptide antagonist drug screening | Melanocortin 4 Receptor MC4R (high selectivity); Weak secondary binding to MC3R, MC5R, MC1R |
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