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| Product name | ASB20123 |
| Description | ASB20123 is a chimeric peptide of C-type natriuretic peptide (CNP) and ghrelin. It retains NPR-B receptor agonistic activity, and the C-terminal basic amino acid cluster prolongs half-life and enhances growth plate enrichment, potently promotes endochondral ossification, and is applied in mechanism research of achondroplasia, growth disorders and dwarfism. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight | ~4.2 kDa (with disulfide bridge) |
| Structure type | CNP(1-22)-ghrelin(12-28, E17D) chimeric peptide |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| ASB20123 | ASB20123; CNP/ghrelin chimeric peptide; Long-acting bone growth peptide | NPR-B receptor agonist,Promotes endochondral ossification,Growth disorder study,Achondroplasia research,Long half-life,Growth plate targeted enrichment | Glycine-leucine-serine-lysine-glycine-cysteine-phenylalanine-glycine-leucine-lysine-leucine-aspartic acid-arginine-isoleucine-glycine-serine-methionine-serine-glycine-leucine-glycine-cysteine-valine-glutamine-glutamine-arginine-lysine-aspartic acid-serine-lysine-lysine-proline-proline-alanine-lysine-leucine-glutamine-proline-arginine (cyclized via Cys6-Cys22 disulfide bridge) | Large peptide, no precise small-molecule formula; subject to actual batch MS | - | ~4200 (theoretical) | Free amine | Free carboxyl | 39 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-ASB001 | White to off-white lyophilized powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted. **Strictly prohibited from strong reducing agents** | Solid powder stable for 2 years at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Good water solubility, freely soluble in water and acidic buffer**. Disulfide bridge is sensitive to reducing agents and prone to cleavage. Easily degraded under alkaline conditions | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ASB001 | CNP/ghrelin chimeric long-acting peptide that targets growth plate to promote bone growth, applied in achondroplasia research | ASB20123 is a chimeric peptide optimized for bone growth. The N-terminus retains the complete human CNP(1-22) active domain, which specifically activates natriuretic peptide receptor B (NPR-B), triggers the cGMP signaling pathway, promotes chondrocyte proliferation and differentiation, and accelerates endochondral ossification. The C-terminus is fused with an engineered ghrelin(12-28) fragment, which enhances binding to the growth plate extracellular matrix through the BX7B motif and basic amino acid cluster, prolongs local retention time and increases plasma half-life. Compared with native CNP, it has stronger bone targeting, longer in vivo half-life and significantly enhanced bone growth activity with no obvious cardiovascular side effects, serving as a core tool molecule for mechanism research of achondroplasia, dwarfism, bone growth disorders and long-acting bone growth drug development. | Achondroplasia research,Growth disorder mechanism study,Bone development research,Long-acting peptide drug development,Natriuretic peptide pathway study,Dwarfism research | Natriuretic Peptide Receptor B (NPR-B); cGMP signaling pathway; Chondrocyte proliferation and endochondral ossification pathway |
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