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| Product name | CAS:113-78-0:Demoxytocin |
| Description | Demoxytocin is a long-acting oxytocin derivative with N-terminal deamination for improved metabolic stability. It activates oxytocin receptors to promote uterine smooth muscle contraction and lactation reflex, applied in labor induction, postpartum hemostasis and reproductive endocrine mechanism research. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₄₃H₆₆N₁₂O₁₂S₂ |
| Molecular weight (Da) | 979.19 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Demoxytocin | Demoxytocin; Deaminooxytocin; CAS 113-78-0; Long-acting oxytocin analog | Oxytocin receptor agonist,Uterine contraction,Lactation promotion,Labor induction study,Postpartum hemostasis study,Long-acting hormone derivative | β-Mercaptopropionic acid-tyrosine-isoleucine-glutamine-asparagine-cysteine-proline-leucine-glycinamide (cyclized via Mpa1-Cys6 disulfide bridge, N-terminal deaminated) | C₄₃H₆₆N₁₂O₁₂S₂ | 978.44 | 979.19 | N-terminal deaminated, no free amine | Amidation | 9 (with unnatural Mpa terminus) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-DEM001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles. **Strictly prohibited from strong reducing agents** | Solid powder stable for 6 months at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Good water solubility, freely soluble in water and dilute acetic acid**. Disulfide bridge is sensitive to strong reducing agents and prone to cleavage. Aqueous stability is weaker than modified peptides, easily degraded at room temperature | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-DEM001 | N-terminally deaminated long-acting oxytocin analog that promotes uterine contraction and lactation, with better metabolic stability than native oxytocin | Demoxytocin is a structural analog of native oxytocin. The N-terminal cysteine is replaced with β-mercaptopropionic acid to remove the free amine, significantly enhancing resistance to aminopeptidase degradation. Its in vivo half-life is 3-5 times that of native oxytocin, with correspondingly improved biological activity. It specifically binds to oxytocin receptors on uterine smooth muscle and mammary myoepithelial cells, activates GPCR pathways, increases intracellular calcium concentration, induces rhythmic uterine smooth muscle contraction, and simultaneously promotes contraction of myoepithelial cells around mammary alveoli to trigger the lactation reflex. With stronger potency and longer duration than native oxytocin, it serves as a classic tool peptide for reproductive endocrinology, parturition physiology, postpartum hemostasis and lactation mechanism research. | Reproductive endocrinology research,Parturition physiology study,Postpartum hemostasis study,Lactation mechanism research,Oxytocin pathway research,Gynecological pharmacology research | Oxytocin Receptor (OXTR); Uterine smooth muscle contraction pathway; Lactation reflex pathway; Calcium signaling pathway |
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