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| Product name | CAS:1379746-42-5:Astodrimer (development code SPL7013) |
| Description | Astodrimer is an anionic dendrimer. High-density surface sulfonic acid groups bind to viral gp120 and block adhesion and entry of HIV, HSV and other viruses to host cells. Applied in mucosal antiviral, viral entry mechanism and microbicide research. |
| Purity (HPLC+SEC) | 95%/98%/99% |
| Average molecular weight | ~10.5 kDa (polydisperse polymer, MW is average value) |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Astodrimer | Astodrimer; SPL7013; CAS 1379746-42-5; Antiviral dendrimer | HIV/HSV viral blockade,Mucosal antiviral,Dendrimer,Microbicide,Viral entry inhibition,Broad-spectrum antiviral | Polylysine core 4th-generation dendritic backbone, terminally conjugated with naphthalene disulfonic acid groups | Polydisperse macromolecule, no precise small-molecule formula | - | ~10500 (average) | No free amine, all terminals modified with sulfonic acid groups | No free carboxyl, 3D dendritic structure | No traditional linear sequence, branched dendrimer |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-AST001 | white powder | Store at -20℃, sealed and dry. Stable for several days at room temperature during shipping | Solid powder stable for 2 years at 2-8℃ sealed and dry; aqueous solutions have long-term stability | Stable for 3 months at 4℃; stable for several weeks at room temperature. **Excellent water solubility, freely soluble in water and physiological buffer**. Excellent chemical stability, not sensitive to temperature, reducing agents or light | Stable for over 3 years at -20℃ under dry conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-AST001 | Anionic dendrimer broad-spectrum antiviral agent that blocks viral envelope protein adhesion, mucosal administration prevents HIV/HSV infection | Astodrimer is a 4th-generation anionic dendrimer based on a polylysine backbone. High-density naphthalene disulfonic acid groups are covalently conjugated to the surface via amide bonds, forming a strongly negatively charged spherical 3D structure. It binds to viral envelope glycoproteins such as HIV gp120 and HSV gD via electrostatic and hydrophobic interactions, masks the virus-host receptor binding sites, and physically blocks virus adhesion and membrane fusion to target cells, thereby inhibiting viral entry. Effective against multiple enveloped viruses including HIV-1, HIV-2, HSV-1 and HSV-2, it does not enter cells and has low cytotoxicity, with high safety for mucosal administration. It serves as a core tool molecule for viral entry mechanism research, mucosal microbicide development and broad-spectrum antiviral drug screening. | Virology research,HIV infection mechanism research,HSV infection research,Mucosal antiviral research,Microbicide development,Viral entry blockade research | Viral envelope glycoproteins (gp120/gD); Virus-cell adhesion and fusion blockade pathway; Electrostatic masking of viral binding sites |
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