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| Product name | CAS:1809080‑14‑5:Relamorelin acetate |
| Description | Relamorelin is a new‑generation highly selective growth hormone secretagogue receptor 1a (GHSR‑1a, i.e. Ghrelin receptor) agonist. Amino acid modifications significantly enhance enzymatic degradation resistance and in vivo half‑life. It specifically binds to GHSR‑1a receptors, promotes growth hormone (GH) secretion, while enhancing gastric motility and accelerating gastric emptying, and also has effects on appetite regulation and energy metabolism. Applied in mechanism research of diabetic gastroparesis, functional dyspepsia, growth hormone deficiency and other diseases, as well as gastrointestinal motility peptide drug development. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~3300 (subject to actual synthetic batch) |
| Structure type | Site‑modified Ghrelin analog, acetate salt |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Relamorelin acetate | Relamorelin acetate; RM-131; Ghrelin receptor agonist | Prokinetic, Growth hormone promotion, GHSR-1a agonism, Gastroparesis research, Appetite regulation, Gastrointestinal motility peptide | Ghrelin homology backbone with site modifications for improved enzyme resistance and receptor affinity | Large modified peptide, subject to actual batch MS | - | ~3300 (theoretical) | Acetate | ~28 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-REL002 | white powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 1 month at 2-8℃ sealed & dry; prepare aqueous solutions freshly before use | Stable for 72h at 4℃; stable for 1 month at -20℃ in aliquots. **Good water solubility, freely soluble in neutral physiological buffer**. DPP-IV resistance significantly improved, but still prone to endopeptidase degradation | Stable for 2 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-REL002 | Highly selective GHSR-1a agonist that promotes gastric motility, accelerates gastric emptying and induces growth hormone secretion | Relamorelin binds to the G protein-coupled GHSR-1a receptor with high specificity and affinity, activates the downstream Gq/11-mediated PLC-IP3-Ca²⁺ signaling pathway, and exerts multiple biological effects: centrally, it acts on the pituitary to promote growth hormone synthesis and release; peripherally, it acts on gastrointestinal smooth muscle and the enteric nervous system, enhances antral contraction, coordinates gastroduodenal motility, accelerates gastric emptying, and improves gastroparesis symptoms. It can also act on the hypothalamic feeding center to regulate appetite and energy metabolism. Compared with native Ghrelin, its site modification avoids rapid enzymatic cleavage by DPP-IV, extending in vivo half-life by several folds with longer lasting effect. | Diabetic gastroparesis, Functional dyspepsia, Growth hormone secretion research, Gastrointestinal motility disorders, Appetite & energy metabolism, Gastrointestinal peptide drugs | Growth Hormone Secretagogue Receptor 1a (GHSR-1a); PLC-IP3-Ca²⁺ signaling pathway; Gastric motility regulation and growth hormone secretion pathway |
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