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| Product name | CAS:39698-78-7:Saralasin acetate hydrate |
| Description | Saralasin is a competitive angiotensin II antagonist. It blocks AT1 receptors to inhibit vasoconstriction and aldosterone secretion, applied in mechanism research of hypertension and the renin-angiotensin system. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Anhydrous free base formula | C₄₂H₆₅N₁₃O₁₀ |
| Anhydrous free base MW (Da) | 912.05 |
| Salt form | Acetate hydrate (acetate and crystal water count subject to actual batch) |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Saralasin acetate hydrate | Saralasin acetate hydrate; CAS 39698-78-7; AT1 receptor antagonist | Angiotensin II receptor antagonism,Antihypertensive activity,Hypertension research,RAAS system research,Competitive antagonist | Sarcosine-arginine-valine-tyrosine-valine-histidine-proline-alanine (linear octapeptide, N-terminal sarcosine = N-methylglycine) | Varies with acetate and crystal water; anhydrous free base C₄₂H₆₅N₁₃O₁₀ | 911.49 (anhydrous free base) | 912.05 (anhydrous free base) | N-terminal methylation (sarcosine) | Free carboxyl | 8 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-SAR001 | white powder | Store at -20℃, protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 2 years at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 24 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Freely soluble in water and dilute acetic acid**. Poor aqueous stability, easily degraded by peptidases, rapidly inactivated at room temperature. Avoid strong oxidizing agents to prevent tyrosine oxidation | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-SAR001 | Competitive angiotensin II receptor antagonist that blocks AT1 receptors for antihypertensive effect, applied in hypertension and RAAS system research | Saralasin is a structural analog of angiotensin II, with sarcosine substitution at position 1 and alanine substitution at position 8 to achieve receptor binding without activation, acting as a competitive antagonist. It specifically binds to angiotensin II type 1 receptors (AT1) on vascular smooth muscle and adrenal cortex, competitively blocks endogenous angiotensin II binding, thereby inhibiting vasoconstriction, reducing aldosterone secretion, and lowering peripheral resistance and blood pressure. This molecule is a classic tool peptide for renin-angiotensin-aldosterone system (RAAS) pathogenesis research, hypertension pharmacological experiments and novel antihypertensive drug screening. | Hypertension research,RAAS system research,Vascular function research,Antihypertensive drug development,Endocrine metabolism research,Aldosterone secretion regulation research | Angiotensin II Type 1 Receptor (AT1R); Vascular smooth muscle contraction pathway; Aldosterone secretion regulatory pathway |
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