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| Product name | CAS:76712-82-8:Histrelin |
| Description | Histrelin is a potent gonadotropin-releasing hormone (GnRH) receptor agonist. D-amino acid and C-terminal ethylamine modification improve metabolic stability. Long-term administration downregulates pituitary GnRH receptors and suppresses gonadotropin secretion. Applied in mechanism research of prostate cancer, central precocious puberty and reproductive endocrinology. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Molecular formula | C₆₆H₈₆N₁₈O₁₂ |
| Molecular weight (Da) | 1323.51 |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | N-terminal Modification | C-terminal Modification | Sequence Length (aa) |
| Histrelin | Histrelin; CAS 76712-82-8; GnRH agonist | GnRH receptor agonist,Pituitary desensitization,Gonadotropin suppression,Prostate cancer research,Precocious puberty research,Reproductive endocrine regulation | Pyroglutamic acid-histidine-tryptophan-serine-tyrosine-D-histidine(benzyl)-leucine-arginine-proline-ethylamine (C-terminal ethylamine substitution, with D-benzylhistidine unnatural modification) | C₆₆H₈₆N₁₈O₁₂ | 1322.67 | 1323.51 | N-terminal pyroglutamate cyclization, no free amine | C-terminal ethylamination, no free carboxyl | 9 (core backbone with unnatural modifications) |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-HIS001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 6 months at 2-8℃ sealed and dry; prepare aqueous solutions freshly before use | Stable for 48 h at 4℃; stable for 2 weeks at -20℃ in aliquots. **Freely soluble in water and dilute acetic acid**. Contains tryptophan residue prone to photooxidation. Aqueous solution easily hydrolyzed by peptidases, poor room-temperature stability | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-HIS001 | Potent GnRH receptor agonist that achieves pituitary desensitization and gonadal axis suppression with long-term administration, applied in prostate cancer and precocious puberty research | Histrelin is a second-generation synthetic gonadotropin-releasing hormone (GnRH) analog. D-benzylhistidine substitution at position 6 and C-terminal ethylamine modification significantly enhance receptor affinity and metabolic stability, with biological activity dozens of times that of native GnRH. Initial administration transiently stimulates pituitary gonadotropin secretion, while continuous administration achieves pituitary desensitization via receptor internalization and downregulation, suppresses LH and FSH synthesis and release, and reduces gonadal hormone levels to achieve medical castration. This molecule is widely used in pharmacological research of prostate cancer, central precocious puberty and endometriosis, and serves as a classic tool peptide for reproductive endocrine regulation and GnRH receptor pathway studies. | Prostate cancer research,Central precocious puberty research,Reproductive endocrine research,Gonadal axis regulation research,GnRH pathway research,Antitumor drug development | GnRH Receptor (GnRHR); Pituitary-gonadal axis regulatory pathway; Gonadotropin secretion and receptor desensitization pathway |
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