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| Description | PA22-2 (CAS: 131435-36-4) is a 19-residue synthetic peptide of laminin alpha chain residues 2091-2108, sequence Cys-Ser-Arg-Ala-Arg-Lys-Gln-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg, molecular formula C82H150N32O25S, MW 2016.33 Da. Compared with the free-acid form (CAS 123063-31-0, MW 2017.32), this form carries a different capping and MW. It contains the potent cell-adhesion sequence IKVAV, promoting neurite outgrowth, Schwann-cell migration, and cell adhesion; widely used in nerve regeneration, ECM-mimetic surfaces, and cell-culture substrate research. |
| Structure type | Linear 19-mer (laminin alpha chain 2091-2108 fragment, IKVAV-containing) |
| Solubility | Readily soluble in water, dilute acetic acid |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| PA22-2 (laminin A-chain IKVAV neurite-outgrowth peptide, C-terminal amide) | PA22-2 amide; CSRARKQAASIKVAVSADR-NH2; Cys-Laminin A chain 2091-2108; IKVAV sequence; laminin α1 chain fragment (residues 2091-2108); C-terminal amidated; same sequence as free-acid version (PEP-PA222FA-01, CAS 123063-31-0) but different terminal chemistry; CAS: 131435-36-4 | cell adhesion, laminin-derived, IKVAV motif, neurite outgrowth, neuronal differentiation, neural tissue engineering, ECM peptide, C-terminal amidation, cationic amphipathic | 19-aa linear cationic cell-adhesion peptide, sequence Cys-Ser-Arg-Ala-Arg-Lys-Gln-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg-NH2; derived from mouse laminin α1 chain (laminin A chain) residues 2091–2108; core active motif IKVAV (Ile-Lys-Val-Ala-Val, positions 11–15); C-terminal carboxyl amidated (-CONH2); N-terminal free Cys with free thiol (-SH); side-chain net charge ~+4 (3 Arg + 2 Lys - 1 Asp; C-amidation removes the C-terminal −1), ~+5 including N-terminus; hydrophobic residues ~42% (8/19, mainly Ala5/Ile1/Val2), amphipathic; one free N-terminal Cys thiol prone to oxidative dimerization; no Met/Trp (no photo-oxidation); this amidated version shares the sequence with the free-acid version (CAS 123063-31-0, C82H149N31O26S) but differs at the C-terminus (−COOH → −CONH2; net −O +N +H), giving C82H150N32O25S | C82H150N32O25S | 2015.12 | 2016.36 | Free amide form, no counterion; C-terminally amidated (−CONH2); free-acid version C82H149N31O26S (exact 2014.12 / avg 2017.35 Da, CAS 123063-31-0); amidation gives −O +N +H → C82H150N32O25S; N-terminal free Cys thiol; CAS: 131435-36-4 | 19 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-PA222-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~3 years). Aliquot to avoid repeated freeze-thaw. Contains a free N-terminal Cys thiol prone to oxidative dimerization-store under argon/nitrogen. | 2–8°C for up to ~2 years; working aliquots at -20°C (a trace of reductant such as 0.1 mM DTT may prevent Cys dimerization, but dialyze it out before experiments). | Cationic amphipathic peptide; good water solubility (aqueous buffers ≥1–5 mg/mL); soluble in DMSO. KEY: The N-terminal Cys carries a free thiol (−SH) that readily oxidizes to an intermolecular disulfide dimer in solution, reducing activity-prepare fresh working solutions or treat with a low concentration of reductant (0.1 mM TCEP/DTT) immediately before use; C-terminus is amidated (no free carboxylate); avoid strong oxidants; no Met (no oxidation), no Trp (no photo-oxidation); weigh quickly and reseal. | solid stable for ~3 years at -20°C, sealed, desiccated, under inert gas (argon/nitrogen). The Cys thiol is reasonably stable in the dry solid, but minimize air exposure by repeated opening. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-PA222-01 | A C-terminally amidated IKVAV neurite-outgrowth peptide derived from laminin α1 chain that promotes neurite extension, neuronal differentiation and neurite-like process formation-widely used in neural tissue engineering and nerve regeneration. | This peptide derives from mouse laminin α1 chain (laminin A chain/G1 domain) residues 2091–2108 and contains the canonical IKVAV (Ile-Lys-Val-Ala-Val) cell-adhesion motif. PA22-2 is a key laminin-derived neuroactive peptide: by binding cell-surface laminin receptors (including the 67 kDa laminin receptor/RPSA and integrin α1β1), it promotes neurite outgrowth, stimulates neurite-like process formation, and-when presented on IKVAV-functionalized scaffolds (hydrogels/nanofibers)-directs neuronal differentiation and axon extension. This is the C-terminally amidated version: amidation resists carboxypeptidase degradation, improves peptidase stability, and removes the C-terminal negative charge to enhance the cationic character. The N-terminal Cys can be used for covalent immobilization onto supports (e.g., maleimide-activated biomaterials) to present IKVAV on scaffolds for regenerative niches. It shares the 19-aa sequence with the free-acid version (CAS 123063-31-0), differing only in terminal chemistry; biological activity is equivalent. Note that the free N-terminal Cys thiol oxidizes readily-use solutions promptly after preparation. | Neurite outgrowth, neuronal differentiation, neural tissue engineering, nerve regeneration, cell adhesion, laminin receptor, biomaterial surface modification, stem-cell neuronal induction | 67 kDa laminin receptor (RPSA/ribosomal protein SA); laminin-binding integrins such as α1β1; laminin G-domain (LG) interactions |
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