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| Description | Arg-Gly-Asp-Ser (RGDS, TFA salt) is a conserved tetrapeptide adhesion sequence found on fibronectin, fibrinogen α, and von Willebrand factor; it binds cell-surface integrins, inhibiting thrombin-induced platelet-fibrinogen interaction. RGDS also directly and specifically binds pro-caspase-8, pro-caspase-9, and pro-caspase-3 (not pro-caspase-1), supporting integrin-signaling and apoptosis research. Free base C₁₅H₂₇N₇O₈, MW 433.42 Da; TFA salt C₁₇H₂₈F₃N₇O₁₀, MW 547.45 Da; the TFA form improves aqueous solubility. |
| Structure type | Linear RGD tetrapeptide (TFA salt) |
| Solubility | Readily soluble in water |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| RGDS TFA (Arg-Gly-Asp-Ser trifluoroacetate; one of the minimal RGD core tetrapeptides) | RGDS TFA; Arg-Gly-Asp-Ser; H-Arg-Gly-Asp-Ser-OH; minimal RGD core tetrapeptide; classic cell-attachment peptide; TFA salt; baseline control/tool peptide for RGD experiments; no CAS | cell adhesion peptide, RGD motif, minimal RGD tetrapeptide, integrin ligand, cell-attachment peptide, RGD assay control, integrin antagonist screening, TFA salt, hygroscopic | Linear tetrapeptide, sequence Arg-Gly-Asp-Ser (RGDS), H-Arg-Gly-Asp-Ser-OH; free N-terminal amine and free C-terminal carboxyl; near-neutral net charge (zwitterionic: 1 Arg - 1 Asp, N-terminus +, C-terminus -, ~0 at neutral pH); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); one of the minimal RGD integrin-recognition core tetrapeptides-the Asp side-chain carboxyl together with Gly and the Arg side chain forms the core triad recognized by multiple RGD-dependent integrins; supplied as the trifluoroacetate (TFA) salt; no CAS number | C17H28F3N7O10 | 547.18 | 547.44 | TFA (trifluoroacetate); free peptide C15H27N7O8 (exact ~433.2 / avg ~433.4 Da) plus one CF3COOH (~+114.0 Da); no CAS number. For cell-culture or in-vivo work requiring a low-irritancy counterion, consider switching to the acetate salt. | 4 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-RGDSTFA-01 | White to off-white powder (TFA salt is strongly hygroscopic) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and photo-oxidation risk. The TFA salt is strongly hygroscopic: aliquot and store sealed in a desiccator. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Small zwitterionic peptide with good water solubility (mg/mL grade in pure water/aqueous buffer, near-neutral and readily soluble). No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The TFA lyophilate is strongly hygroscopic-weigh quickly after opening, reseal immediately, and avoid repeated freeze-thaw. As a baseline RGD control/competitor, prepare working solutions directly in medium or buffer; for cell or in-vivo work requiring a low-irritancy counterion, consider the acetate salt. | solid stable for ~2 years at -20°C, sealed and desiccated. The TFA salt is strongly hygroscopic-keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-RGDSTFA-01 | The trifluoroacetate salt of RGDS, one of the minimal RGD core tetrapeptides; a classic cell-attachment peptide binding alpha5 beta1/alphaV integrins and the baseline control/tool peptide for RGD cell-adhesion experiments. | RGDS is one of the minimal tetrapeptides containing the canonical Arg-Gly-Asp (RGD) motif, mimicking the RGD cell-adhesion site of extracellular-matrix proteins such as fibronectin; it is the most widely used baseline tool peptide in RGD/integrin research. Its RGD triad (Arg side chain, Gly, Asp side-chain carboxyl) is recognized by alpha5 beta1 and alphaV-class integrins (alphaV beta3, alphaV beta5). As a soluble competitor, RGDS blocks RGD-dependent cell adhesion and spreading; as an immobilized ligand it promotes cell attachment. Typical uses: (1) baseline/positive control peptide for RGD-dependent cell adhesion; (2) studies of integrin-ligand structural specificity (compared with RGE negative controls or cyclic RGD peptides); (3) competitive reference peptide in integrin antagonist/small-molecule inhibitor screening; (4) cell attachment and spreading mechanism studies. Note that linear RGDS has far lower integrin affinity than cyclized RGD analogues and is used mainly for controls and mechanistic work. Supplied as the TFA salt, which is strongly hygroscopic-weigh quickly and store dry/sealed; for cell culture or in-vivo work, prefer a low-irritancy counterion such as acetate to reduce TFA effects on cells. | Cell adhesion, integrin biology, RGD signaling, cell attachment, integrin antagonist screening, RGD assay controls, biomaterial-cell interactions | RGD-dependent integrins alpha5 beta1, alphaV (alphaV beta3/alphaV beta5); cell-ECM adhesion and spreading pathways |
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