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| Description | Collagen binding peptide (Collagen-Binding Fragment, CAS: 94040-53-6) is a decapeptide fragment encoding the collagen-binding domain of fibronectin, sequence Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr (CQDSETRTFY), molecular formula C₅₂H₇₆N₁₄O₂₀S, MW 1249.31 Da. The peptide selectively binds type I collagen and serves as a targeting sequence to deliver functional molecules (e.g., heparin, drug carriers) to collagen-rich extracellular matrix, for tissue-targeted delivery, decellularized-tissue functionalization, and matrix-interaction research. |
| Structure type | Linear 10-mer (fibronectin type-I collagen-binding-domain fragment) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Collagen Binding Peptide (fibronectin collagen-binding fragment) | CQDSETRTFY; Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr; Fibronectin Collagen Binding Fragment; CAS 94040-53-6 | collagen-binding peptide, fibronectin collagen-binding domain, collagen mimetic, cell-matrix interactions, tissue engineering, collagen receptor | Linear 10-aa peptide Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr (CQDSETRTFY), derived from the high-affinity collagen-binding loop within the 30-kDa collagen-binding domain (tandem type-I FN repeats) of human fibronectin; the N-terminal Cys corresponds to the native disulfide/cyclization site (present as a free thiol in the isolated 10-mer and prone to oxidative dimerization); net charge ~-1 (Arg +1, Asp -1, Glu -1); contains Phe/Tyr hydrophobic residues and several polar hydroxyl residues (Ser/Thr×2); solubility moderate-to-good in water | C52H76N14O20S | 1248.51 | 1249.31 | Free base (no counterion); formula C52H76N14O20S (exact 1248.51 / avg 1249.31 Da); CAS 94040-53-6 | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CBP-01 | White to off-white powder (contains a free thiol at Cys; protect under nitrogen/reducing agent to prevent oxidative dimerization) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot and store under nitrogen to protect the N-terminal Cys free thiol from oxidative disulfide dimerization; 0.1–1 mM DTT/TCEP may be used as temporary protection. No Trp-low photolysis risk. | 2–8°C, desiccated, for up to ~1 month; working aliquots at -20°C, preferably under nitrogen. | Moderate-to-good water solubility (high polar-residue content, but Phe/Tyr make it mildly hydrophobic; ~1–3 mg/mL in pure water; ≥10 mg/mL in DMSO then dilute into aqueous buffer). Contains a free Cys thiol prone to oxidative dimerization in solution-prepare fresh and add a low concentration of reducing agent (0.5–1 mM TCEP); avoid repeated freeze-thaw. | solid stable for ~2 years at -20°C, sealed, desiccated, under nitrogen. The Cys thiol is oxidation-sensitive; deliquescence or prolonged air exposure causes disulfide dimerization and activity loss. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CBP-01 | A 10-aa fragment (CQDSETRTFY) of the human fibronectin collagen-binding domain that binds native and denatured collagen (gelatin) with high affinity, mediating cell-matrix adhesion and collagen-matrix assembly; widely used to coat tissue-engineering scaffolds, for collagen-targeted delivery, and to probe collagen-receptor interactions. | This product is a 10-residue functional fragment-Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr (CQDSETRTFY)-of the 30-kDa collagen-binding domain of human fibronectin, the region built from tandem type-I FN modules (F11–F5) that binds collagens I/II/III and denatured collagen (gelatin). Fibronectin engages collagen through this domain to drive connective-tissue assembly, wound repair and cell-matrix bridging; CQDSETRTFY retains the key recognition residues of this interface and acts as a minimal functional unit that directly binds the collagen-fibril surface. Its biological uses include: (1) as a collagen-targeting ligand to coat tissue-engineering scaffolds, hydrogels and nanoparticles, improving cell adhesion, spreading and proliferation on collagen matrices; (2) to dissect collagen-cell interactions and the recognition specificity of collagen receptors such as integrin α2β1 and DDR1/2; (3) as a competitive probe for collagenases/MMP substrates and collagen-binding proteins (e.g., SPARC, collectins); and (4) in collagen-targeted drug delivery, gelatin-affinity-mimetic chromatography and cell-sheet engineering. The N-terminal Cys provides a thiol handle for facile maleimide coupling to PEG, liposomes, gold nanoparticles or material surfaces. The isolated peptide contains a single free cysteine and is oxidation-sensitive; store under nitrogen or with a reducing agent. | Tissue engineering, collagen-matrix biology, cell-matrix interactions, collagen-targeted drug delivery, gelatin-affinity chromatography, regenerative medicine, wound repair | Collagens I/II/III and gelatin; integrin α2β1; collagen receptors DDR1/DDR2; fibronectin collagen-binding domain (F1 modules); MMP/collagenase substrates |
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