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| Description | RGDSPASSKP (CAS: 91575-25-6) is a fibronectin decapeptide containing the RGDS core, sequence Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro, molecular formula C40H68N14O16, MW 1001.05 Da. It extends the C-terminal sequence beyond the RGD core and is used to study integrin-recognition specificity and conformational effects of longer fibronectin cell-binding fragments, as well as RGD-mediated cell adhesion, spreading, migration, and platelet-aggregation inhibition, a standard tool peptide for integrin-ECM interaction research. |
| Structure type | Linear 10-mer (RGDS-core-containing fibronectin extended sequence) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| RGDSPASSKP (fibronectin cell-binding domain decapeptide with RGD integrin-binding motif) | Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro; RGD decapeptide; fibronectin FN-III10 cell-binding domain fragment; CAS 91575-25-6; Sigma A6677; fibronectin binding inhibitor; free base powder | cell adhesion, fibronectin, RGD motif, integrin ligand, αvβ3, α5β1, integrin inhibitor, cell migration, angiogenesis, tissue engineering, wound healing | Linear decapeptide, sequence Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro (R-G-D-S-P-A-S-S-K-P); contains the canonical RGD (Arg-Gly-Asp) tripeptide integrin-binding core motif; derived from the 10th type III fibronectin repeat (FN-III10) cell-binding domain; side-chain net charge +1 (Arg +1, Lys +1, Asp -1); N-terminal +1 and C-terminal -1 cancel out, giving overall net charge ~+1; hydrophobic residues 30% (Pro×2, Ala×1, total 3/10); no Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation); all-L-amino acid native sequence; acts as a competitive inhibitor of integrin-fibronectin interaction | C40H68N14O16 | 1000.49 | 1001.07 | Free base, powder; no salt variant; CAS 91575-25-6 | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-RGDSP-01 | White to off-white powder | Store at -20°C, sealed, dry, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and aggregation risk. | 2–8°C for up to ~1 month; working aliquots at -20°C. Stable for shipping at ambient temperature. | Small linear peptide with good water solubility (aqueous buffer ≥5–10 mg/mL); contains one acidic Asp side chain and basic Arg/Lys side chains, overall near-neutral to slightly basic (net charge ~+1). No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Weigh quickly after opening and reseal immediately. For cell culture use, prepare in sterile PBS or water and filter through 0.22 μm. | solid stable for ~2 years at -20°C, sealed and dry. Moderate hygroscopicity-store in a desiccator. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-RGDSP-01 | A fibronectin-derived RGD decapeptide integrin ligand containing the canonical RGD core motif. Competitively inhibits integrin-fibronectin binding and is widely used in cell adhesion, migration, angiogenesis, and integrin-targeted drug research. | This is a decapeptide fragment derived from the central cell-binding domain (CCBD, FN-III9-10) of fibronectin, retaining the native RGD (Arg-Gly-Asp) integrin recognition core motif. RGD is the most classic integrin-binding site found in extracellular matrix proteins. This peptide competitively binds RGD-dependent integrins including αvβ3, αvβ5, α5β1, and αIIbβ3, blocking cell adhesion to fibronectin, vitronectin, and fibrinogen. In cancer research, RGD peptides competitively inhibit tumor cell adhesion and migration, and can be conjugated as targeting ligands to drugs or nanoparticles for tumor neovasculature imaging and delivery. In tissue engineering, immobilized RGD peptides promote cell attachment and proliferation. As a short linear peptide with limited membrane permeability but good water solubility, it is suitable for integrin receptor binding assays, cell adhesion inhibition assays, and as an RGD positive control peptide. | Cell adhesion, integrin biology, tumor angiogenesis, tissue engineering, wound healing, drug delivery, regenerative medicine, biomaterial surface modification | αvβ3, αvβ5, α5β1, αIIbβ3 and other RGD-dependent integrins; fibronectin-integrin adhesion interface; cell migration and FAK signaling pathway |
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