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| Description | RGD peptide (GRGDNP) (TFA) is the TFA salt of the RGD-motif-containing hexapeptide, sequence Gly-Arg-Gly-Asp-Asn-Pro. Free base C₂₃H₃₈N₁₀O₁₀, MW 614.62 Da; TFA salt C₂₅H₃₉F₃N₁₀O₁₂, MW 728.63 Da. Via the RGD motif, GRGDNP binds integrin receptors and plays an important role in cell adhesion, migration, growth, and differentiation; the TFA form improves aqueous solubility for integrin-mediated cell-behavior research. |
| Structure type | Linear 6-mer (GRGDNP, TFA salt) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| RGD peptide (GRGDNP), TFA salt | GRGDNP TFA; Gly-Arg-Gly-Asp-Asn-Pro·TFA; RGD mimetic TFA salt; CAS 114681-65-1 (free peptide) | RGD analog, integrin ligand, cell adhesion, TFA salt, integrin-ECM interaction inhibitor | Linear 6-aa peptide Gly-Arg-Gly-Asp-Asn-Pro (GRGDNP) as the trifluoroacetate (TFA) counterion salt; retains the RGD tripeptide core with Asn at position 5; free peptide net charge ~+1 (Arg +1 / Asp -1), TFA as counterion; no cysteine, no disulfide bond; the standard form obtained after RP-HPLC purification, with improved solubility | C23H38N10O10 | 614.28 | 614.62 | TFA salt (trifluoroacetate counterion); free-peptide formula C23H38N10O10 (exact 614.28 / avg 614.62 Da); TFA-salt formula C25H39F3N10O12 (exact 728.27 / avg 728.64 Da); CAS 114681-65-1 | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRGDNP-TFA-01 | White to off-white powder (TFA salt; more hygroscopic than the free base) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. The TFA salt is hygroscopic-after opening, equilibrate in a desiccator and weigh quickly in a dry environment; avoid repeated air exposure. | 2–8°C, desiccated, for up to ~1 month; working aliquots at -20°C. | Excellent water solubility (the TFA salt dissolves very readily in water/PBS, ≥10 mg/mL); the TFA counterion improves -cake reconstitution. Prepare fresh; stable at 4°C for 1–2 days. Note: at high concentrations TFA is mildly cytotoxic-dialyze or buffer-exchange before sensitive cell assays. | solid stable for ~2 years at -20°C, sealed and desiccated. The TFA salt is hygroscopic and must be kept sealed over desiccant; deliquescence leads to aggregation and activity loss. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRGDNP-TFA-01 | The TFA-counterion form of GRGDNP (Gly-Arg-Gly-Asp-Asn-Pro), identical in sequence and biology to the free base: a competitive ligand for RGD-dependent integrins (α5β1 etc.) that blocks cell–ECM adhesion and triggers anoikis; the TFA salt reconstitutes rapidly at high concentration for adhesion/migration assays. | This is the trifluoroacetate (TFA) salt of the 6-aa peptide GRGDNP (Gly-Arg-Gly-Asp-Asn-Pro); the peptide sequence, RGD tripeptide core and biological activity are identical to the free base. GRGDNP TFA competitively binds RGD-recognizing integrins (predominantly α5β1, and also αvβ3 and αvβ5), blocking their interaction with ECM ligands such as fibronectin and vitronectin and dose-dependently inhibiting cell adhesion, spreading and focal-adhesion formation. In vitro it perturbs stress-fiber assembly, suppresses cell migration and proliferation, and, by disengaging integrin–ECM survival signaling (the anoikis pathway), promotes conformational activation and autoprocessing of pro-caspase-3, inducing tumor-cell apoptosis. The TFA salt is the customary output of RP-HPLC purification and lyophilization: the cake reconstitutes almost instantly and the aqueous solubility is high (≥10 mg/mL), making it convenient for adhesion-inhibition and integrin competition assays that require fresh high-concentration stock. Note that TFA is a strong-acid counterion and is mildly irritating to primary cells, sensitive cell lines and in vivo injection at high doses; for salt-sensitive work choose the free base (PEP-GRGDNP-01) or exchange TFA to acetate/HCl by dialysis, SPE or HPLC before use. | Cell adhesion & migration, integrin biology, tumor anoikis, angiogenesis, RP-HPLC-purified peptide standards, ECM-cell interactions | Integrin α5β1 (primary); integrin αvβ3, αvβ5; pro-caspase-3 apoptotic pathway; RGD-binding sites of fibronectin/vitronectin |
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