![[Glp1]-FGL Peptide Acetate](/uploads/48442/-glp1-fgl-peptide-acetate6446d.jpg)
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| Description | [Glp1]-FGL peptide acetate (CAS: 499993-62-3) is a 15-residue peptide derived from the interconnecting loop of the second fibronectin type III module of the neural cell adhesion molecule (NCAM), N-terminally capped with pyroglutamic acid (pGlu), sequence pGlu-Val-Tyr-Val-Val-Ala-Glu-Asn-Gln-Gln-Gly-Lys-Ser-Lys-Ala, MW 1631.81 Da. FGL peptide mimics the NCAM-FGF receptor (FGFR) interaction, activating FGFR1 signaling to promote neurite outgrowth and synaptic function, and is blood-brain-barrier penetrant; it is an important tool peptide in neuroprotection, cognition, and neurodegeneration research. |
| Structure type | Linear 15-mer (N-terminal pGlu, acetate salt) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| [Glp1]-FGL peptide acetate (NCAM-derived FGFR-agonist neuroprotective mimetic, N-terminal pyroglutamate, acetate salt) | [Glp1]-FGL peptide; FGL peptide acetate; FG Loop peptide; pEVYVVAENQQGKSKA; pGlu-VYVVAENQQGKSKA; H-pGlu-Val-Tyr-Val-Val-Ala-Glu-Asn-Gln-Gln-Gly-Lys-Ser-Lys-Ala-OH; NCAM FnIII-2 loop peptide; FGFR1 agonist; acetate salt; no CAS | neuroprotection, neural cell adhesion molecule, NCAM mimetic, FGFR1 agonist, FGFR signaling, neurite outgrowth, synaptic plasticity, cognition enhancement, blood-brain barrier penetrant, acetate salt, N-terminal pyroglutamate | Linear 15-aa amphipathic neuroprotective mimetic peptide; N-terminal Glu cyclized to pyroglutamate (Glp/pGlu, loss of one H2O); sequence pEVYVVAENQQGKSKA (pGlu-VYVVAENQQGKSKA, free C-terminal acid), derived from the FG loop of the second fibronectin type III (FnIII-2) module of neural cell adhesion molecule (NCAM/NCAM1, P13591). N-terminal pyroglutamate blocks exopeptidase degradation and improves stability; near-neutral net charge (2 Lys +1, remaining Glu side chain -1, free C-terminus -1; N-terminal Glu cyclized to a neutral lactam); contains 1 Tyr and 2 Gln, no Cys/Met/Trp (no disulfide/Met oxidation/severe photo-oxidation); ~33% hydrophobic residues (Val4/Ala2/Ile) forming a weak hydrophobic face; excellent water solubility (reported >=100 mg/mL in water) | C71H114N20O24 | 1630.83 | 1631.81 | Acetate salt; the basic-info formula is given for the free pyroglutamylated peptide C71H114N20O24 (exact 1630.83 / avg 1631.81 Da); plus one acetic acid CH3COOH (+60.02 Da) for the acetate form. Obtained from the linear parent EVYVVAENQQGKSKA (C71H116N20O25, MCE CAS 499993-62-3) by N-terminal Glu-to-pGlu cyclization (-H2O); no CAS number | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FGLP-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid freeze-thaw. No Met/Cys-low oxidation risk; contains 1 Tyr, so avoid strong UV/prolonged light. The acetate salt is moderately hygroscopic-weigh quickly and store dry/sealed. | 2–8°C for ~1 month; working aliquots at -20°C (or -80°C), sealed and desiccated; stable for shipping at ambient. | Excellent water solubility (reported >=100 mg/mL in water); near-neutral and predominantly hydrophilic-no DMSO needed. N-terminal pyroglutamate and free C-terminal carboxylate confer solubility in neutral buffers. No Cys/Met-low oxidation risk; 1 Tyr-avoid strong light. The acetate lyophilate is somewhat hygroscopic-weigh quickly, filter-sterilize (0.22 um) working solutions, aliquot and avoid repeated freeze-thaw. | solid stable ~2 years at -20°C, sealed and desiccated; the N-terminal pyroglutamylated/free-acid form is stable-keep dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FGLP-01 | A 15-aa FGFR1-agonist mimetic from the NCAM FnIII-2 FG loop, N-terminally pyroglutamylated; activates NCAM-FGFR signaling to promote neurite outgrowth and neuroprotection, crosses the blood-brain barrier, for stroke / TBI / cognitive-decline research. | This is the N-terminally pyroglutamylated acetate form of FGL, a synthetic mimetic derived from the FG loop of the second fibronectin type III module of neural cell adhesion molecule (NCAM). FGL mimics the NCAM–FGFR1 interaction, binding and activating FGFR1 and downstream PLCgamma, MAPK/ERK and PI3K-Akt signaling: in vitro it promotes neurite outgrowth and neuronal survival and is neuroprotective in oxygen-glucose-deprivation models; in vivo it crosses the blood-brain barrier after subcutaneous dosing, reduces age-related microglial activation and inflammatory cytokines, improves synaptic and dendritic-spine structure, and enhances social memory and cognition. Preclinical models cover traumatic brain injury (TBI), transient global ischemia/stroke, Alzheimer's disease and age-related cognitive decline. N-terminal pyroglutamate (Glp) confers aminopeptidase resistance and prolongs half-life; supplied as acetate, a low-irritancy counterion suitable for cell and in-vivo use. | Neuroscience, neuroprotection, neurodegeneration, stroke, traumatic brain injury, cognition and synaptic plasticity, anti-neuroinflammation, peptide drug development | FGFR1 / NCAM-FGFR complex; downstream PLCgamma, MAPK/ERK and PI3K-Akt neuronal survival and synaptic-plasticity pathways; blood-brain barrier penetration |
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