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| Description | EILDV (CAS: 150525-67-0) is the pentapeptide of residues 1978-1982 of the CS-1 domain in the type III connecting segment (IIICS) of human, bovine, and rat fibronectin, sequence Glu-Ile-Leu-Asp-Val, molecular formula C26H45N5O10, MW 587.67 Da. It is the non-RGD recognition site for integrin alpha4beta1 (VLA-4): immobilized on surfaces it promotes tumor-cell adhesion, while the soluble form inhibits experimental metastasis of B16-BL6 melanoma and other tumor cells. EILDV is used to study CS-1-mediated cell adhesion, lymphocyte homing, and tumor-metastasis mechanisms. |
| Structure type | Linear 5-mer (fibronectin CS-1 domain 1978-1982, VLA-4-binding) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| EILDV (human, bovine, rat) - fibronectin CS1 LDV-motif pentapeptide | Glu-Ile-Leu-Asp-Val; LDV motif peptide; fibronectin CS-1 fragment (residues 1978-1982); H-Glu-Ile-Leu-Asp-Val-OH; CAS 150525-67-0; human/bovine/rat conserved; IIICS region; VLA-4 ligand | cell adhesion, fibronectin, CS1 fragment, LDV motif, VLA-4, α4β1, α4β7, leukocyte migration, inflammation, lymphocyte homing, autoimmunity | Linear pentapeptide, sequence Glu-Ile-Leu-Asp-Val (E-I-L-D-V); contains the LDV (Leu-Asp-Val) integrin-binding core motif; represents the minimal active sequence of the CS1 fragment within the fibronectin IIICS (alternatively spliced V region); the sequence is fully conserved across human, bovine, and rat; side-chain net charge -2 (Glu -1, Asp -1); N-terminal +1 and C-terminal -1 cancel out, giving overall net charge ~-2; hydrophobic residues 60% (Ile, Leu, Val, total 3/5), relatively hydrophobic; no Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation); all-L-amino acid native sequence; selectively binds α4 integrin family (does not bind RGD-dependent integrins) | C26H45N5O10 | 587.32 | 587.67 | Free base, powder; CAS 150525-67-0; identical sequence across human, bovine, and rat species | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-EILDV-01 | White to off-white powder | Store at -20°C, sealed, dry, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation risk. | 2–8°C for up to ~1 month; working aliquots at -20°C. Stable for shipping at ambient temperature. | Small pentapeptide with moderate to good water solubility (~2–5 mg/mL in aqueous buffer; contains two acidic side chains with overall negative charge-may first dissolve in dilute ammonia or DMSO then dilute with water). One Glu and one Asp acidic side chain, overall negatively charged (net charge ~-2). No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Weigh quickly after opening and reseal. | solid stable for ~2 years at -20°C, sealed and dry. Low hygroscopicity-store in a desiccator. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-EILDV-01 | A fibronectin CS1-derived LDV pentapeptide integrin ligand that selectively binds VLA-4 (α4β1) and α4β7 integrins, mediating leukocyte-endothelial adhesion and transendothelial migration. A key tool peptide for inflammation and lymphocyte homing research. | This is a pentapeptide fragment derived from the CS1 domain within the fibronectin IIICS (type III connecting segment, alternatively spliced V region), retaining the LDV (Leu-Asp-Val) tripeptide integrin recognition core motif. Unlike the canonical RGD motif, the LDV motif selectively recognizes the α4 integrin family: it primarily binds VLA-4 (α4β1) and α4β7 integrins, but not RGD-dependent integrins such as αvβ3 or α5β1. VLA-4 is expressed on lymphocytes, monocytes, and eosinophils, and is a critical adhesion molecule for leukocyte trafficking to inflammatory sites. EILDV competitively inhibits VLA-4-mediated cell adhesion and is used as a tool peptide in research on autoimmune diseases (multiple sclerosis, rheumatoid arthritis, asthma), inflammatory responses, lymphocyte homing, and leukemia cell migration. The LDV motif is the minimal active sequence within the CS1 fragment, with flanking residues (N-terminal Glu-Ile) providing binding affinity support. | Cell adhesion, integrin biology, inflammation, lymphocyte homing, autoimmune disease, leukocyte migration, asthma, multiple sclerosis, tumor metastasis | VLA-4 (α4β1) integrin; α4β7 integrin; fibronectin CS1 fragment binding site; leukocyte-endothelial adhesion and transendothelial migration pathway |
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