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| Description | H-Ile-Lys-Val-Ala-Val-OH (IKVAV, CAS: 131167-89-0) is a bioactive pentapeptide derived from the α1 chain of laminin, sequence Ile-Lys-Val-Ala-Val, molecular formula C₂₅H₄₈N₆O₆, MW 528.70 Da. IKVAV exhibits pro-angiogenic activity, promotes neurite outgrowth, and modulates macrophage phenotype via integrin mediation; it is an important functional peptide in neural tissue engineering, angiogenesis, and immunomodulation research. |
| Structure type | Linear 5-mer (laminin α1-chain derived) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| H-Ile-Lys-Val-Ala-Val-OH (IKVAV), laminin α1-chain-derived neurite-active pentapeptide, free base | IKVAV; Ile-Lys-Val-Ala-Val; laminin A-chain active fragment; H-Ile-Lys-Val-Ala-Val-OH; CAS 131167-89-0 | Laminin-derived peptide, IKVAV, neurite outgrowth, nerve regeneration, α3β1/α6β1 integrin binding, cell adhesion, neural stem cells | Linear pentapeptide H-Ile-Lys-Val-Ala-Val-OH; derived from the IKVAV neurite-active sequence in the globular region of the animal laminin α1 chain (formerly the A chain); rich in hydrophobic residues (Ile/Val/Ala/Val) with only Lys charged, net charge ~+1 (Lys + N-term +1, C-term -1); relatively hydrophobic with moderate water solubility; no Cys/Met/Trp; CAS 131167-89-0 | C25H48N6O6 | 528.36 | 528.70 | Free base (no salt counterion); formula C25H48N6O6 (exact 528.36 / avg 528.70 Da); CAS 131167-89-0 | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-IKVAV-01 | White to off-white powder (free base; hydrophobic residues predominate, moderate hygroscopicity) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Cys/Met/Trp-low oxidation risk. As a free base it carries no TFA counterion (lowest irritation); because it is relatively hydrophobic, weigh quickly and reseal in a desiccator. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Hydrophobic pentapeptide with moderate water solubility (many Ile/Val/Ala/Val residues). Pre-dissolve in a small volume of DMSO, then dilute into PBS/aqueous buffer to the working concentration; it can also be dissolved directly in aqueous buffer with gentle sonication. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Prepare fresh or store working aliquots at -20°C and avoid repeated freeze-thaw; with no counterion it is well suited to neuronal and neural-stem-cell culture. | solid stable for ~2 years at -20°C, sealed and desiccated. Keep the desiccator sealed and the weighing environment dry to avoid moisture-induced caking. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-IKVAV-01 | The free-base neurite-active pentapeptide IKVAV derived from the laminin α1 chain (A chain). It binds α3β1/α6β1 integrins and heparan-sulfate proteoglycans/sulfated glycolipids, potently promotes neurite outgrowth and neuronal migration, supports neural-stem-cell differentiation, and is a classic functional motif for nerve regeneration and neural tissue engineering. | This is the free-base neurite-active pentapeptide IKVAV (Ile-Lys-Val-Ala-Val) derived from the laminin α1 chain (formerly the A chain), representing one of the core epitopes by which laminin promotes neurite outgrowth. IKVAV engages cell-surface α3β1 and α6β1 integrins and interacts with heparan-sulfate proteoglycans/sulfated cell-surface glycolipids (and the laminin-binding protein LBP110), triggering focal-adhesion and intracellular signaling that drives neurite extension and neuronal migration. In vitro, IKVAV coated onto culture plates, hydrogels or scaffold surfaces markedly enhances neurite outgrowth, neuronal spreading and axonal guidance, and modulates the survival, proliferation and neuronal differentiation of neural stem/progenitor cells. In vivo and in tissue-engineering studies, IKVAV is often immobilized on conduits, hydrogels or biomaterials to guide peripheral-nerve regeneration, support spinal-cord injury repair and bionically modify neural scaffolds, recapitulating the neural microenvironment of native laminin. Being relatively hydrophobic with moderate water solubility, pre-dissolve it in a small volume of DMSO before diluting into aqueous buffer; supplied as a free base with no TFA/acetate counterion, it has the lowest cytotoxicity/irritancy and is suited to neuronal studies and in-vivo implant materials; containing no Cys/Met/Trp, oxidation and photo-oxidation risks are low. | Nerve regeneration, neurite outgrowth, neural-stem-cell differentiation, peripheral-nerve/spinal-cord injury repair, neural tissue engineering, hydrogel/scaffold biomimetic modification, neural development, cell adhesion | Integrins α3β1, α6β1; heparan-sulfate proteoglycans/sulfated glycolipids; LBP110 laminin-binding protein; neurite-outgrowth and neuronal-migration signaling |
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