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| Description | Gly-Arg-Gly-Asp-Ser (GRGDS, CAS: 96426-21-0) is the active pentapeptide fragment of the fibronectin cell-binding domain, sequence Gly-Arg-Gly-Asp-Ser, molecular formula C₁₇H₃₀N₈O₉, MW 490.47 Da. GRGDS contains the RGD motif and competitively inhibits integrin-mediated cell adhesion to fibronectin; it is used in cell-adhesion mechanism, platelet-function, and tissue-engineering surface-functionalization research. |
| Structure type | Linear 5-mer (fibronectin active fragment, RGD-containing) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Gly-Arg-Gly-Asp-Ser (GRGDS), classic RGD-core pentapeptide, free base | GRGDS; Gly-Arg-Gly-Asp-Ser; RGD-core pentapeptide; H-Gly-Arg-Gly-Asp-Ser-OH; CAS 96426-21-0 | RGD peptide, integrin ligand, cell adhesion, fibrinogen binding, free base | Linear pentapeptide H-Gly-Arg-Gly-Asp-Ser-OH; contains the canonical RGD (Arg-Gly-Asp) integrin-recognition core, extended at the N-terminus by Gly and capped at the C-terminus by Ser; net side-chain charge ~0 (Arg +1 / Asp -1, plus N-term +1 / C-term -1); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation); good water solubility; CAS 96426-21-0 | C17H30N8O9 | 490.21 | 490.47 | Free base (no salt counterion); formula C17H30N8O9 (exact 490.21 / avg 490.47 Da); CAS 96426-21-0 | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GRGDS-01 | White to off-white powder (free base; less hygroscopic than the TFA salt) | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Cys/Met/Trp-low oxidation risk. As a free base it carries no TFA counterion (lowest irritation), suiting cell and in-vivo studies; still weigh quickly and reseal in a desiccator (or under nitrogen). | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Short RGD peptide with good water solubility, readily dissolved in aqueous buffers (PBS, pure water) at ≥5–10 mg/mL. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). Prepare fresh or store working aliquots at -20°C and avoid repeated freeze-thaw; with no counterion it is well suited to salt-sensitive cell-adhesion and platelet assays. | solid stable for ~2 years at -20°C, sealed and desiccated. The free base is less hygroscopic than the TFA salt, but keep the desiccator sealed and the weighing environment dry. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GRGDS-01 | The free-base form of the classic RGD-core pentapeptide Gly-Arg-Gly-Asp-Ser. It contains the minimal integrin-recognition RGD motif, competitively binds cell-surface integrins (αIIbβ3, αvβ3, α5β1, etc.), mediates cell-matrix adhesion and fibrinogen binding, and is widely used as a cell-adhesion control and integrin-antagonism research tool. | This is the free-base form of the classic RGD-core pentapeptide GRGDS (Gly-Arg-Gly-Asp-Ser); its core Arg-Gly-Asp sequence is the minimal structure specifically recognized by integrins within extracellular-matrix (ECM) proteins such as fibrinogen, fibronectin, vitronectin and osteopontin. Through its RGD tripeptide core, GRGDS engages the ligand-binding pocket of cell-surface integrin heterodimers-especially αIIbβ3 (GPIIb/IIIa), αvβ3, αvβ5 and α5β1-mimicking the adhesion signals delivered by native ECM ligands. On platelets, GRGDS competitively occupies the fibrinogen-binding site of αIIbβ3, blocking fibrinogen bridging and platelet aggregation; on adherent cells, it competitively blocks attachment to fibronectin/vitronectin-coated surfaces, serving as a negative control for integrin-specific adhesion and a dose-dependent adhesion inhibitor. With an N-terminal Gly and a C-terminal Ser, the short backbone offers better solubility and conformational stability than the free RGD tripeptide, supporting studies of cell adhesion, migration, spreading, actin-cytoskeleton reorganization and FAK/paxillin focal-adhesion signaling downstream of integrins. Supplied as a free base with no TFA/acetate counterion, it has the lowest cytotoxicity/irritancy and is especially suited for salt-sensitive cell culture and in-vivo studies; containing no Cys/Met/Trp, oxidation and photo-oxidation risks are low, and it dissolves well in aqueous buffers. | Cell adhesion, integrin biology, platelet aggregation, tumor metastasis, angiogenesis, tissue-engineering scaffold modification, biomaterial surface modification, peptide lead discovery | Integrins αIIbβ3 (GPIIb/IIIa), αvβ3, αvβ5, α5β1; fibrinogen/fibronectin binding sites; FAK/paxillin focal-adhesion signaling |
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