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| Description | PA22-2 free acid (CAS: 123063-31-0) is a 19-residue synthetic peptide of laminin alpha chain segment 2091-2108 (free-acid C-terminus), sequence Cys-Ser-Arg-Ala-Arg-Lys-Gln-Ala-Ala-Ser-Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg, molecular formula C82H149N31O26S, MW 2017.32 Da. It contains the potent cell-adhesion sequence IKVAV, promoting neurite outgrowth, Schwann-cell migration, and epithelial-cell adhesion. PA22-2 is widely used to study laminin-integrin/dystroglycan interactions, nerve-regeneration scaffold materials, and ECM-mimetic surfaces; the free-acid form improves aqueous solubility. |
| Structure type | Linear 19-mer (Cys-laminin A chain 2091-2108 fragment, IKVAV-containing, free acid) |
| Solubility | Readily soluble in water, dilute acetic acid |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| PA22-2 free acid (Cys-laminin A chain residues 2091-2108, IKVAV neurite-outgrowth peptide) | PA22-2 free acid; CSRARKQAASIKVAVSADR; Cys-laminin A chain 2091-2108; laminin alpha1-chain-derived IKVAV active peptide; N-terminal Cys for conjugation; CAS 123063-31-0; TargetMol T81575 | cell adhesion peptide, laminin ligand, IKVAV motif, neurite outgrowth, angiogenesis, biomaterial coating, N-terminal Cys conjugation, cationic peptide, free acid | Linear 19-mer, sequence CSRARKQAASIKVAVSADR, corresponding to laminin alpha1 (A) chain residues 2091-2108 with an additional N-terminal cysteine (Cys1) for thioether/maleimide or thiol-gold/resin conjugation; free C-terminal carboxyl (free acid, -COOH); net charge ~+4 (3 Arg + 2 Lys - 1 Asp, including N-terminus); no Met/Trp/His; a single cysteine (no intramolecular disulfide, free thiol); the core pentapeptide IKVAV (Ile-Lys-Val-Ala-Val, residues 11-15) is the minimal functional site mediating laminin-driven neurite outgrowth and cell adhesion | C82H149N31O26S | 2016.10 | 2017.35 | Free acid (C-terminal -COOH); no counterion salt; N-terminal free thiol (-SH)-handle as a reducing thiol peptide | 19 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-PA222-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot and store under argon to avoid repeated freeze-thaw. The N-terminal free cysteine thiol readily oxidizes to a disulfide dimer-store the lyophilate under argon/vacuum and include 2-5 mM DTT or TCEP in working solutions. No Met/Trp-low oxidation and photo-oxidation risk. | 2–8°C for up to ~1 month; working aliquots at -20°C (with reducing agent). Short-term ambient shipping is acceptable. | Cationic peptide with good water solubility (aqueous buffers ≥1–5 mg/mL). KEY NOTE: the N-terminal Cys is a free thiol that air-oxidizes to a disulfide dimer in solution, lowering conjugation efficiency-prepare fresh, or protect with 2-5 mM DTT/TCEP, and remove the reductant by desalting before the coupling reaction. No Met (no oxidation), no Trp (no photo-oxidation). The IKVAV region is somewhat hydrophobic; at high concentration the peptide can self-assemble into nanofibrils/amyloid-like aggregates, so prepare fresh working solutions. | solid stable for ~2 years at -20°C under argon-sealed, anaerobic and dry conditions; weigh quickly. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-PA222-01 | PA22-2, a 19-mer derived from laminin alpha1 chain, containing the classic IKVAV neurite-outgrowth motif and an N-terminal Cys for conjugation; promotes cell adhesion, spreading, migration and neurite extension, widely used in neural tissue engineering and biomaterial functionalization. | This is the synthetic 19-mer PA22-2 corresponding to laminin alpha1 (A) chain residues 2091-2108, a classic mimetic of laminin's cell-adhesion and neurite-outgrowth activity. Its core activity is mediated by the IKVAV pentapeptide (residues 11-15): it competes with intact laminin for the laminin receptor and promotes attachment, spreading, directional migration and axonal/neurite extension of neurons, endothelial cells and tumor cells, and participates in angiogenesis. Beyond neurobiology, early work (PNAS, 1990) showed that this segment also stimulates tumor-cell collagenase IV production and a metastatic phenotype. The engineered N-terminal free cysteine (Cys1) provides a specific thiol-coupling handle for site-directed immobilization onto biomaterial scaffolds, supported phospholipid bilayers, gold surfaces or carrier proteins (KLH/BSA), making it a standard tool for neural tissue engineering, pro-regenerative biomaterials and functionalized cell-culture surfaces. Supplied as the free acid (C-terminal -COOH; not amidated, not a TFA salt); because of the free thiol, protect from oxidation during storage and solution preparation (argon; DTT/TCEP if needed). | Cell adhesion, neurite outgrowth/neural regeneration, angiogenesis, laminin receptor, neural tissue engineering, biomaterial surface functionalization, tumor invasion and metastasis, peptide-scaffold conjugation | Laminin receptor (beta1-integrin-containing); IKVAV-mediated cell attachment and neurite-extension pathways; endothelial-cell migration and angiogenesis |
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