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| Description | RGDV (CAS: 93674-99-8) is the tetrapeptide variant of the fibronectin cell-binding core motif Arg-Gly-Asp (RGD), sequence Arg-Gly-Asp-Val, molecular formula C17H31N7O7, MW 445.48 Da. The RGD motif is the shared recognition sequence by which integrins bind ECM proteins such as fibronectin, vitronectin, and fibrinogen; RGDV competitively inhibits cell-matrix adhesion and platelet-fibrinogen interaction. This tetrapeptide is commonly used to probe the minimal active length of RGD, build integrin-binding surface coatings and tissue-engineering scaffolds, and study cell-adhesion signaling, serving as a basic tool peptide in cell biology and biomaterials. |
| Structure type | Linear 4-mer (RGD integrin-recognition motif variant) |
| Solubility | Readily soluble in water, PBS buffer |
| Storage | Powder -20C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| RGDV (Arg-Gly-Asp-Val; minimal RGD integrin-recognition tetrapeptide) | RGDV; Arg-Gly-Asp-Val; H-Arg-Gly-Asp-Val-OH; minimal RGD integrin-antagonist tetrapeptide; CAS 93674-99-8 | cell adhesion peptide, RGD motif, integrin antagonist, integrin ligand, cell adhesion inhibitor, anti-platelet/thrombosis research, free acid | Linear tetrapeptide, sequence Arg-Gly-Asp-Val (RGDV), H-Arg-Gly-Asp-Val-OH; free N-terminal amine and free C-terminal carboxyl (free acid, -COOH); near-neutral net charge (zwitterionic: 1 Arg - 1 Asp, N-terminus +, C-terminus -, ~0 at neutral pH); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); the minimal RGD cell-adhesion recognition motif derived from fibronectin-the Asp side-chain carboxyl together with Gly and the Arg side chain forms the core triad recognized by multiple RGD-dependent integrins (alphaV beta3, alphaV beta5, alphaIIb beta3, etc.) | C17H31N7O7 | 445.23 | 445.48 | Free acid (C-terminal -COOH); no counterion salt | 4 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-RGDV-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and photo-oxidation risk; the small-molecule lyophilate is stable. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Small zwitterionic peptide with excellent water solubility (aqueous buffers ≥10 mg/mL). No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The lyophilate is only weakly hygroscopic-routine sealing suffices. As a soluble integrin antagonist, prepare working solutions directly in medium or buffer; for specificity controls, RDGV or RGEV mutants are commonly used to demonstrate RGD dependence. | solid stable for ~2 years at -20°C, sealed and desiccated; routine desiccator storage is sufficient. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-RGDV-01 | The minimal RGD integrin-recognition tetrapeptide Arg-Gly-Asp-Val; as a soluble competitor it blocks RGD-dependent integrins (alphaV beta3/alphaV beta5/alphaIIb beta3) and is a classic tool peptide in integrin biology and anti-adhesion research. | RGDV is one of the minimal tetrapeptides containing the canonical Arg-Gly-Asp (RGD) motif, mimicking the RGD cell-adhesion site of extracellular-matrix proteins such as fibronectin, vitronectin and fibrinogen. As a small soluble competitor, RGDV binds and blocks multiple RGD-dependent integrins-including alphaV beta3 and alphaV beta5 (tumor angiogenesis, tumor-cell migration) and alphaIIb beta3 (platelet GPIIb/IIIa, platelet aggregation)-thereby inhibiting cell adhesion and spreading on ECM-coated surfaces. Typical uses: (1) as a competitive inhibitor/positive control for RGD-dependent cell adhesion; (2) studying integrin-ligand structural specificity (compared with RGE, RGDV derivatives or cyclic RGD peptides); (3) mechanistic studies of tumor angiogenesis, metastasis and platelet aggregation/thrombosis; (4) soluble competition controls in studies of biomaterial-surface RGD ligand density versus cellular response. Note: linear RGDV has far lower integrin affinity than cyclized RGD analogues (e.g., cyclo-RGDfK) and is used for mechanistic/control experiments rather than potent antagonism. Supplied as the free acid with no counterion, suitable for cell and in-vivo studies. | Cell adhesion, integrin biology, RGD signaling, tumor angiogenesis/metastasis, platelet aggregation and thrombosis, biomaterial-cell interactions, adhesion inhibitors | RGD-dependent integrins alphaV beta3, alphaV beta5, alphaIIb beta3 (GPIIb/IIIa); cell-ECM adhesion and spreading pathways |
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