Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of thrombospondin-derived adhesion peptide vtcg (val-thr-cys-gly, free acid, free thiol) in China, also supports custom service. Welcome to wholesale bulk high quality thrombospondin-derived adhesion peptide vtcg (val-thr-cys-gly, free acid, free thiol) from our factory. Contact us for more details.
| Description | H-Val-Thr-Cys-Gly-OH (VTCG, CAS: 131204-46-1) is a linear tetrapeptide with an internal cysteine, sequence Val-Thr-Cys-Gly, molecular formula C₁₄H₂₆N₄O₆S, MW 378.44 Da; N-terminal hydrophobic Val, internal polar Thr and thiol-bearing Cys, net charge 0 at pH 7. This low-MW peptide is used for studies of peptide solubility behavior, thiol-based conjugation, and stability, and as a model peptide in protein-peptide interaction research. |
| Structure type | Linear 4-mer (internal Cys thiol) |
| Solubility | Sparingly soluble in water; soluble in DMSO (net charge 0 at neutral pH) |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Thrombospondin-derived Adhesion Peptide VTCG (Val-Thr-Cys-Gly, free acid, free thiol) | VTCG; H-Val-Thr-Cys-Gly-OH; Val-Thr-Cys-Gly; core motif of TSP-1 type-1 repeat CSVTCG; CD36-binding peptide; free-cysteine thiol linker/immobilization peptide; free acid; CAS 131204-46-1 | cell adhesion, thrombospondin TSP-1, CSVTCG core motif, CD36, anti-angiogenesis, endothelial apoptosis, platelet aggregation, tumor metastasis, free cysteine, thiol immobilization, oxidation-sensitive | Linear 4-aa short peptide, sequence Val-Thr-Cys-Gly (V-T-C-G); side-chain net charge ~0 (Val/Thr/Gly are neutral; only the Cys thiol, no charged side chains; zwitterionic only via the terminal alpha-amino/alpha-carboxyl); contains ONE FREE CYSTEINE THIOL (-SH) with no pairing disulfide bond-this is the defining structural feature: under oxidizing conditions the free thiols of two VTCG molecules spontaneously form a cystine-type dimer (VTCG-S-S-VTCG) and lose activity; this tetrapeptide is the conserved core motif within the canonical hexapeptide CSVTCG (Cys-Ser-Val-Thr-Cys-Gly) of thrombospondin-1 (TSP-1) type-1 repeats (TSR); in native TSP-1 the two cysteines of CSVTCG are cyclized by a disulfide, whereas the VTCG monomer retains the Val-Thr-Cys-Gly core recognized by CD36 while its free thiol enables site-directed conjugation/immobilization via maleimide, iodoacetamide, gold surfaces or thiol-disulfide exchange; supplied as the free acid; CAS 131204-46-1 | C14H26N4O6S | 378.16 | 378.44 | Free acid (H-Val-Thr-Cys-Gly-OH); no added counterion; CAS 131204-46-1 | 4 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-VTCG-01 | White to off-white powder (free thiol-supplied/recommended sealed under argon/inert gas) | Store at -20°C, sealed, DESICCATED, protected from light, UNDER ARGON (or nitrogen/inert gas) (~1–2 years). Aliquot to avoid repeated freeze-thaw. This peptide carries one unpaired free cysteine thiol that is highly oxidation-sensitive: the lyophilate slowly oxidizes to the VTCG-S-S-VTCG dimer on exposure to air/oxygen. Weigh quickly under inert gas and immediately reseal under argon; keep in a desiccator. Avoid contact with oxidants and heavy-metal ions (Cu2+/Fe3+). | 2–8°C under argon-sealed conditions for ~1–2 weeks; prepare working solutions fresh, store remaining aliquots under argon at -20°C and use promptly; do not repeatedly freeze-thaw. | Neutral short peptide with a free Cys thiol; soluble in aqueous buffers (neutral/weakly alkaline pH; ~1–5 mg/mL). ⚠️ THE MAJOR RISK IS FREE-THIOL OXIDATION: in aqueous solution exposed to air it gradually forms the cystine dimer (VTCG-S-S-VTCG, ~754 Da), abolishing CD36-binding/conjugation activity. Requirements: (1) degas solvents and saturate with argon/nitrogen before use; (2) prepare working solutions fresh and use the same day under argon-sealed conditions; (3) avoid oxidants (H2O2, hypochlorite) and heavy-metal ions (Cu2+/Fe3+ catalyze thiol oxidation); use thiol reductants (DTT/TCEP) only with caution and remove before downstream conjugation; (4) do not repeatedly freeze-thaw; (5) for site-directed thiol conjugation (maleimide-activated carriers, gold nanoparticles/surfaces, thiol-reactive resins), perform the coupling on freshly prepared, non-oxidized peptide and verify free-thiol content by Ellman's assay before coupling. The free thiol is the functional handle for covalent, site-directed immobilization. | solid stable for ~1–2 years at -20°C, under argon-sealed, dry, dark conditions. Because of the free thiol, maintain inert-gas sealing and dryness, and minimize air exposure during weighing. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-VTCG-01 | The cell-adhesion tetrapeptide VTCG, core motif of the CSVTCG sequence in thrombospondin-1 (TSP-1) type-1 repeats; it signals through CD36 to mediate anti-angiogenesis, endothelial apoptosis and platelet/tumor-cell adhesion. It carries one free cysteine thiol, serving both as a CD36-targeting adhesion peptide and as a thiol-bearing linker for oriented immobilization; strict inert-gas/anti-oxidation handling is required. | This is the tetrapeptide VTCG (Val-Thr-Cys-Gly), the core of the canonical cell-adhesion/CD36-binding hexapeptide CSVTCG (Cys-Ser-Val-Thr-Cys-Gly) within the type-1 repeats (TSR) of thrombospondin-1 (TSP-1). In native TSP-1, the CSVTCG motif mediates high-affinity binding to the 88-kDa transmembrane glycoprotein CD36 (glycoprotein IV, class B scavenger receptor family) on the cell surface; the TSP-1–CD36 interaction drives endothelial apoptosis, anti-angiogenic signaling, platelet aggregation, and matrix recognition during tumor-cell adhesion and metastasis. VTCG retains the Val-Thr-Cys-Gly core recognized by CD36 and is widely used to study CD36 targeting, anti-angiogenic signaling, and to build cell-adhesive interfaces on peptide-functionalized biomaterials and hydrogels. Unlike the disulfide-cyclized CSVTCG, the VTCG monomer carries one unpaired free cysteine thiol: this -SH is both its main liability (oxidation to the inactive VTCG-S-S-VTCG cystine dimer) and its functional handle-it enables site-directed, oriented conjugation to maleimide-activated resins, gold nanoparticles/surfaces (Au–S bond), or thiol-reactive carriers. Supplied as the free acid: because of the free thiol, the lyophilate must be stored under argon/inert gas, dry, dark, at -20°C; prepare solutions fresh under argon, avoid oxidants and heavy-metal ions, do not repeatedly freeze-thaw, and verify free-thiol content by Ellman's assay before conjugation. | Angiogenesis/anti-angiogenesis research, CD36 receptor biology, endothelial apoptosis, platelet aggregation/thrombosis, tumor-cell adhesion/metastasis, TSP-1 signaling pathways, peptide-functionalized biomaterials/hydrogels, thiol site-directed conjugation and surface immobilization, cell-adhesive interface engineering | CD36 (glycoprotein IV / class B scavenger receptor on endothelium, platelets, macrophages); the TSP-1 type-1 repeat CSVTCG binding site; the free cysteine thiol (-SH) for maleimide/gold/thiol-resin covalent conjugation; downstream anti-angiogenic and endothelial-apoptosis signaling |
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