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| Description | HIV-1 Pol (RT) residues 476–484, an HLA-restricted CD8+ immunodominant epitope; used for HIV-specific CTL responses, immune control and vaccines. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Pol (476-484), HIV-1 RT Epitope (HLA-A*0201-Restricted CD8 CTL Epitope, IV9; CAS 139079-41-7) | HIV-1 RT Pol 476-484; ILKEPVHGV; IV9; PEP-RT476-01 | HIV CTL epitope, HLA-A*0201 restricted, CD8 T cells, tetramer antigen peptide, viral immune escape, T-cell vaccine, hydrophobic epitope peptide, DMSO-assisted | Linear 9-mer, H-Ile-Leu-Lys-Glu-Pro-Val-His-Gly-Val-OH (ILKEPVHGV), free acid (C-terminal -COOH); the classic HLA-A*0201-restricted CD8+ CTL epitope (nonamer IV9) from HIV-1 reverse transcriptase Pol residues 476-484; no Cys/Met/Trp/Tyr | C46H78N12O12 | 990.59 | 991.20 | Not specified (typical TFA salt for synthetic peptides; per COA) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-RT476-01 | White to off-white powder (synthetic linear 9-mer; salt form not specified, typical TFA salt for synthetic peptides) | Store at -20°C, sealed and desiccated, ~2-3 years; no Cys/Met/Trp/Tyr, so chemically stable; aliquot and avoid repeated freeze-thaw. | 2-8°C for ~2-4 weeks; working aliquots at -20°C; avoid repeated freeze-thaw. | Hydrophobic MHC-I epitope peptide (anchored mainly by Ile/Leu/Val); dissolves slowly in water - first dissolve in a small volume of (or pure) DMSO, then dilute with sterile water, pH 7.4 PBS or culture medium (final DMSO usually <=1-5%; for tetramer assembly a 10-20% DMSO stock is commonly used). Lys/Glu/His confer some hydrophilicity, so low-concentration PBS dissolution is also possible; store solutions aliquoted at -20°C and avoid repeated freeze-thaw to prevent aggregation/precipitation. | solid stable ~2-3 years at -20°C, sealed and dry; no oxidation-sensitive residues. If shipped as a TFA salt it is hygroscopic: weigh quickly and reseal with desiccant. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-RT476-01 | The classic HLA-A*0201-restricted CD8+ CTL epitope from HIV-1 reverse transcriptase Pol 476-484 (ILKEPVHGV, IV9), for HIV-specific CD8+ T-cell responses, CTL immune-escape mutations, and peptide-MHC tetramer assembly. | ILKEPVHGV (nonamer, IV9) from HIV-1 Pol (reverse transcriptase) residues 476-484 is one of the earliest identified and most classic HLA-A*0201-restricted CD8+ cytotoxic T-lymphocyte (CTL) epitopes. With N-terminal Ile and C-terminal Val as HLA-A*0201 (P2/P9) anchor residues, it is broadly recognized by HIV-specific CD8+ T cells in infected individuals and is a standard antigen peptide for studying virus-specific CTL response kinetics, CTL escape mutations and T-cell vaccines. IV9 is widely used for: folding peptide-HLA-A*0201 monomers/ tetramers and staining epitope-specific CD8+ T cells; in vitro peptide stimulation/expansion of HIV-specific CTL with IFN-gamma ELISPOT or intracellular cytokine staining; and functional validation of vaccine candidate epitopes and Pol-region immune-escape/drug-resistance mutations. | HIV immunology, CD8 CTL epitope, HLA-A*0201 tetramer, viral immune escape, T-cell vaccine | HLA-A*0201 (HLA-A*02:01) MHC-I molecule; HIV-1 RT (Pol 476-484)-specific TCR |
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